نتایج جستجو برای: medial temporal sclerosis mesialtemporallobe epilepsy
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Background: Epilepsy surgery has become a successful treatment option for patients with drug-resistant epilepsies. Objectives: This study aimed to assess temporal lobe epilepsy (TLE) surgery outcome and its association with epilepsy duration, the presence of pre-surgical generalized tonic-clonic seizure (GTCS), and brain MRI findings. Materials & Methods: This retrospective study was perfo...
Mesial temporal lobe epilepsy (MTLE) is one of the most common types focal in adult population. MTLE frequently associated with a specific histopathological lesion medial structures, namely hippocampal sclerosis (HS). A significant proportion patients MTLE+HS have severe epilepsy, which often resistant to clinical treatment. For these patients, surgical resection epileptogenic can be performed....
Temporal lobe epilepsy with hippocampus sclerosis (HS) is the most frequent focal epilepsy and often refractory to anticonvulsant therapy. Secondary structural damage has been reported in several studies of temporal lobe epilepsy and unilateral hippocampal sclerosis. Applying diffusion tensor imaging (DTI) we investigated alterations in white matter following temporal lobe surgery in patients w...
Commentary The hippocampus is the most frequent target of surgical treatment for epilepsy. Approximately 30% of patients with mesial temporal sclerosis (MTS) on surgical pathology, however, have normal findings on conventional MRI prior to surgery (1). Epilepsy specialists have hoped that ultra-high–field 7-T MRI might improve detection and characterization of MTS for pre-surgical screening (2)...
Epilepsy, hippocampal sclerosis and febrile seizures linked by common genetic variation around SCN1A
Epilepsy comprises several syndromes, amongst the most common being mesial temporal lobe epilepsy with hippocampal sclerosis. Seizures in mesial temporal lobe epilepsy with hippocampal sclerosis are typically drug-resistant, and mesial temporal lobe epilepsy with hippocampal sclerosis is frequently associated with important co-morbidities, mandating the search for better understanding and treat...
BACKGROUND AND PURPOSE The prevalence of hippocampal sclerosis in the general nonepileptic patient population is not well described. While reports of its association with partial complex seizures are abundant, its absence in nonafflicted patients is generally presumed but not well documented. To test the hypothesis that hippocampal sclerosis is specific for epilepsy, we reviewed the MR imaging ...
January 2009 Version 9 TEMPORAL LOBE EPILEPSY: A CLINICAL VIEW POINT Background: Temporal lobe epilepsy (TLE) was defined in 1985 by the International League Against Epilepsy (ILAE) as a condition characterized by recurrent unprovoked seizures originating from the medial or lateral temporal lobe. The seizures associated with TLE consist of simple partial seizures without loss of awareness (with...
The left hippocampus and related structures mediate verbal memory function. The mechanism underlying preserved verbal memory function in patients with left hippocampal damage is unknown. Temporal lobe epilepsy, a common disease, is frequently the consequence of a characteristic hippocampal pathology termed hippocampal sclerosis, which may also affect the amygdala. In this setting, mapping the s...
Role of magnetic resonance imaging for preoperative evaluation of patients with refractory epilepsy.
OBJECTIVE To investigate the magnetic resonance imaging characteristics of patients with refractory epilepsy and the relationship to progression to surgery. DESIGN Prospective observational study. SETTING University teaching hospital, Hong Kong. PATIENTS Patients undergoing preoperative evaluation for epilepsy surgery. MAIN OUTCOME MEASURE Cranial magnetic resonance imaging findings, co...
Functional magnetic resonance imaging has demonstrated reorganization of memory encoding networks within the temporal lobe in temporal lobe epilepsy, but little is known of the extra-temporal networks in these patients. We investigated the temporal and extra-temporal reorganization of memory encoding networks in refractory temporal lobe epilepsy and the neural correlates of successful subsequen...
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