Cardiac auto-regulation involves integrated regulatory loops linking electrics and mechanics in the heart. Whereas mechanical activity is usually seen as 'the endpoint' of cardiac auto-regulation, it is important to appreciate that the heart would not function without feed-back from the mechanical environment to cardiac electrical (mechano-electric coupling, MEC) and mechanical (mechano-mechani...

Angiogenesis, the formation of new capillaries from pre-existing vessels, plays a critical role during bone regeneration and repair. In addition to an appropriate mechanical environment, sufficient supply of oxygen and nutrients is critical for bone formation. Mechano-biological models have been previously used to predict the time course of the differentiation process with the mechanical enviro...

Background Sensitive hearing in Drosophila requires the NOMPC (TRPN1) channel. is a bona fide mechano-electrical transduction (MET) channel whose amino-terminal ankyrin repeat (AR) domain consists of 29 ARs. These ARs assemble into helical structure, tether intracellularly to microtubules, and are essential for mechano-gating. Because these findings it was hypothesized that AR might function as...

Male and female Artemia salina swim in tandem pairs before copulation and during this period the metachronal rhythms of the individuals are entrained. Artemia entrain to pulsatile water stimulation of the head at frequencies between 4 and 6 Hz. The antennules are mechano-sensitive. Antennular responsiveness to phasic input is very probably the actual mechanism by which interorganism co-ordinat...

Magneto-Mechano-Electric Generators In article number 2112028, Sam Nyung Yi, Jongmoon Jang, Geon-Tae Hwang, and co-workers demonstrate a >50 mW RMS-output magneto-mechano-electric generator achieved by hybridization of piezoelectric electromagnetic induction effects. The electric output energy is enough to continuously operate multifunctional IoT sensors, thus enabling verify ambient informatio...

Inter-species differences in regeneration exist in various levels. One aspect is the dynamics of bone regeneration and healing, e.g. small animals show a faster healing response when compared to large animals. Mechanical as well as biological factors are known to play a key role in the process. However, it remains so far unknown whether different animals follow at all comparable mechano-biologi...

Biological tissues like intervertebral discs and articular cartilage primarily consist of interstitial fluid, collagen fibrils and negatively charged proteoglycans. Due to the fixed charges of the proteoglycans, the total ion concentration inside the tissue is higher than in the surrounding synovial fluid (cation concentration is higher and the anion concentration is lower). This excess of ion ...

How the behaviour of somatic stem cells (SCs) is influenced by mechanical signals remains a black-box in cell biology. Here we show that YAP/TAZ regulation by cell shape and rigidity of the extracellular matrix (ECM) dictates a pivotal SC decision: to remain undifferentiated and grow, or to activate a terminal differentiation programme. Notably, mechano-activation of YAP/TAZ promotes epidermal ...