Induction of cytotoxic T lymphocytes (CTL) is critical to cancer vaccine based immunotherapy. Efforts to elicit CTLs against tumor MUC1 with peptide based vaccine have not been successful in clinical application. We have design a MUC1 vaccine by replacing B cell epitope of CTB with MUC1 VNTR peptide. Immunization with hybrid CTB-MUC1 plus aluminum hydroxide and CpG adujuvant (CTB-MUC1-Alum-CpG)...

Self-assembled secondary ZnO nanoparticles, recognized with the agglomeration of crystalline subcrystals, are successfully synthesized by a simple sol-gel method. TEM images display that one artificial cluster behaves in a single-crystal-like wurtzite structure because subcrystals coagulate as the same crystal orientation. Moreover, from the resonant Raman scattering, the as-grown sample exhibi...

Each year in the United States, 3.5 million women unintentionally become pregnant.3 Moreover, approximately 1.5 million abortions are performed annually,4 making the United States' abortion rate one of the highest among Western countries.' Meanwhile, the number of women and children living below the poverty level continues to increase. 6 These facts indicate that women urgently need additional ...

In low dimensional gravity on anti-de sitter space there exists a possibility that the asymptotic isometry is raised to a Virasoro symmetry living at spatial infinity. We discuss in detail asymptotic isometry of the most general anti-de sitter dilaton gravity in two dimensions. From analysis of the boundary dynamics it turns out that the Virasoro symmetry is not preserved in all the models. Mor...

We give a simple and efficient construction of unique signature on groups equipped with bilinear map. In contrast to prior works, our proof of security is based on computational Diffie-Hellman problem in the random oracle model. Meanwhile, the resulting signature consists of only one group element. Due to its simplicity, security and efficiency, our scheme is suitable for those situations that ...

Three dimensional Network-on-chip(3D NoC) is regarded as an attractive architecture delivering high communication performance. However, due to its high power density and strong vertical thermal correlation, thermal issues in 3D NoC are critical. In this paper, we propose a thermal-aware task mapping algorithm (3DTTM) to reduce peak temperature meanwhile minimize the communication energy consump...

A multiobjective optimization problem is considered in a general formulation. It is well known that the solution of the problem is not unique and represented in the objective space by a Pareto frontier. In an engineering design it can be important to provide a discrete representation of the entire Pareto surface. Meanwhile, the obtaining of a single Pareto solution may be time-consuming. Moreov...

Abstract: This paper considers the problem of fault estimation and accommodation for a class of switched systems with time-varying delay. An adaptive fault estimation algorithm is proposed to estimate the fault, moreover, constant or time-varying fault can be estimated. Meanwhile, a delaydependent criteria is obtained with the purpose of reducing the conservatism of the fault estimation algorit...

This paper reports piezoelectrically driven and sensed micromirrors achieving extremely large total optical scan angle of 106° and high frequency of 45 kHz at 22 V. To reach such large angles, extensive FEM-simulations relating to fracture strength of poly-Si, of which these micromirrors primarily consist, have been performed. Meanwhile, high Q-factor of more than 5000 under ambient conditions ...