Drug-resistant tuberculosis is a major public health problem. The aim of this study was to assess the local susceptibility patterns of Mycobacterium tuberculosis and clinical outcomes of drug resistant tuberculosis (DR-TB) at Srinagarind Hospital, a tertiary care center in northeastern Thailand. Between January 2004 and December 2008, 1,052 patients had culture-proven M. tuberculosis infections...

The rise of multidrug-resistant tuberculosis (MDR-TB), defined as tuberculosis showing resistance to at least isoniazid and rifampicin, is a serious threat to tuberculosis control in some high prevalence countries and may have some impact on low prevalence regions as well. The World Health Organization estimates that 50 million people worldwide are infected with MDR-TB, and that, in the year 20...

Drug resistant tuberculosis (DR-TB) has been reported since the early days of introduction of antitubercular chemotherapy, but recently multi drug resistant tuberculosis (MDR-TB), has been an area of growing concern, and is posing threat to global efforts of tuberculosis control. Prevalence of MDR-TB, in a community mirrors the functional state and efficacy of tuberculosis control programme and...

Medicines for tuberculosis. The drugs for the lengthy treatment of MDR-TB can cost more than 100 times that of the drugs to treat common tuberculosis strains. Even in places where tuberculosis control has seen the greatest progress, such as many of the countries in WHO’s Western Pacific Region, the fight against drug-resistant tuberculosis faces huge challenges. “In most of the high-burden coun...

background and objectives: tuberculosis (tb) is the major public health problem in the world. each year there are 2-3 million deaths worldwide caused by tb. the increasing incidence of multi drug resistance tuberculosis (mdr-tb) worldwide highlights the urgent need to search for new anti-tuberculosis compounds. it has been reported that medicinal plant, dracocephalum kotschyi, possesses some an...

Observational data from Eastern Europe on the management and outcome of multi-drug-resistant tuberculosis (MDR TB) in HIV positive populations remain sparse in the English-language literature. We compared clinical characteristics and outcomes of 55 patients who were diagnosed with HIV and MDR TB in Eastern Europe between 2004 and 2006 to 89 patients whose Mycobacterium tuberculosis isolates wer...

The objective: to determine the frequency of resistance Mycobacterium tuberculosis (MTB) most effective anti-tuberculosis drugs in patients Republic Karelia, characterize cases amplification MTB drug during chemotherapy (CT). Subjects and Methods. cultures 1,137 were studied, received from 2016 2021, among them 634 (55.8%) had multiple (MDR). Among MBT with MDR, there was a high extensive (XDR)...

introduction: infections by multidrug resistant mycobacterium tuberculosis (mdr-tb) is a major public health challenge. secretion of proteins by m. tuberculosis plays an important role in the pathogenesis of the bacterium. we compared the protein profiles of susceptible m. tuberculosis and mdr-tb isolates using proteomic analyses, namely two dimensional gel electrophoresis (2de) and mass spectr...

BACKGROUND & OBJECTIVES Multidrug-resistant tuberculosis (MDR-TB) has emerged as a significant global health concern. The most important risk factor for the development of MDR-TB is previous anti-tuberculosis therapy. Category II pulmonary TB includes those patients who had failed previous TB treatment, relapsed after treatment, or defaulted during previous treatment. We carried out this study ...