Mannose-binding lectin-associated serine proteases-1/3 (MASP-1/3) are essential in activating the alternative pathway (AP) of complement through cleaving pro-factor D (pro-Df) into mature Df. MASP are believed to require binding to mannose binding lectins (MBL) or ficolins (FCN) to carry out their biological activities. Murine sera have been reported to contain MBL-A, MBL-C, and FCN-A, but not ...

Our first experience of mannan-binding lectin (MBL)-replacement therapy was with a patient experiencing recurrent erythema multiforme associated with reactivation of herpes simplex virus; his erythematous eruptions could be controlled with infusions of fresh frozen plasma containing MBL, but not with plasma lacking MBL. Some years later, we treated a young girl with recurrent, debilitating infe...

The clinical heterogeneity observed in leptospirosis may be associated with host factors or bacteria virulence. Human serum mannose-binding lectin (MBL) recognizes many pathogens, and low levels of this lectin are associated with susceptibility to infection. MBL is also implicated in the modulation of the inflammatory process. We determined the levels of serum MBL during leptospirosis infection...

PURPOSE The present study was undertaken to detect metallo-beta-lactamase (MBL) in nosocomial isolates of Pseudomonas aeruginosa by four different phenotypic methods. METHODS Ninety-one consecutive P. aeruginosa isolates were subjected to susceptibility testing by disc-diffusion assay and Vitek 2. Imipenem resistance was determined by three different methods (disc-diffusion, Vitek 2 and E tes...

Mannose-binding lectin (MBL; also known as mannan-binding lectin) is an important component of innate immunity. MBL levels are mainly genetically determined. Low serum MBL levels and their cognate haplotypes have been associated with a wide range of infections. However, most subjects with MBL deficiency remain healthy. MBL deficiency is also associated with non-infectious diseases including sys...

Children with cancer often have fever during chemotherapy-induced neutropenia, but only some develop serious infectious complications. Mannose-binding lectin (MBL) deficiency might increase infection susceptibility in these children. MBL genotype and phenotype were prospectively determined in 110 paediatric oncology patients. During febrile neutropenia, MBL concentrations were measured longitud...

Human mannan-binding lectin (MBL) plays a pivotal role in innate immunity. Substantial literature supports the belief that three point mutations, CGT52TGT, GGC54GAC and GGA57GAA, in the collagen-like region (CLR) of the human MBL gene, are associated with increased susceptibility to infection, autoimmunity and carcinogenesis. To investigate the me...

pag. 4 INTRODUCTION: pag. 6 Section 1: Stroke  Epidemiology 7  Risk Factors 8  Major recognized mechanisms for ischemic stroke 8  Pathophysiology of ischemic stroke and SAH 8 Section 2: Immune mechanism of stroke pag. 13  The complement system in stroke 18 The lectin pathway 22 Section 3: MBL in health and disease pag. 24  General features of MBL 24  Human MBL: from gene to protein 25 Th...

Mannose binding lectin (MBL) is an important element of the innate immune system. MBL binding leads to activation and cleavage of C3 and C4 suggesting the role of MBL pathway for opsonization and/ phagocytosis. The role of adaptive immune response in development of pathogenic autoantibodies in various autoimmune diseases is well understood. The link between innate and acquired immunity is helpf...

Introduction: Metallo-beta-lactamase (MBL)-producing Acinetobacter is a therapeutic challenege all over the world. The aims of this study were to determine the prevalence of MBL genes and evaluate the antimicrobial susceptibility profile of carbapenem non-susceptible isolates of Acinetobacter. Material and Method: During a period of 12 months (November 2012 to October 2013) 94 isolates of carba...