Cancer cells, relative to normal cells, demonstrate increased sensitivity to glucose-deprivation-induced cytotoxicity. To determine whether oxidative stress mediated by O(2)(*-) and hydroperoxides contributed to the differential susceptibility of human epithelial cancer cells to glucose deprivation, the oxidation of DHE (dihydroethidine; for O(2)(*-)) and CDCFH(2) [5- (and 6-)carboxy-2',7'-dich...

Resveratrol is a natural polyphenolic compound with cancer chemopreventive activity. However, our understanding of the molecular mechanism responsible for resveratrol-induced apoptosis is still very limited. Here, we used MCF-7 and MDA-MB231 breast cancer cells as a model to demonstrate that resveratrol induced the expression of ASPP1, a new member of the ASPP (apoptosis stimulation protein of ...

Natural phenolic compounds are known not only for their multiple bioactivities but also low bioavailability and rapid metabolism in the systemic circulation. It is well-known that grafting these to bio-based polymers such as hyaluronic acid (HA), has advantage increase stability water solubility. HA CD44 receptors overexpressed on cancer cells. This makes from an interesting vector antitumor dr...

From ethyl acetate-methanol extracts of leaves and twigs of Pseuduvaria trimera a new aporphine alkaloid; 8-hydroxy-1,4,5-trimethoxy-7-oxoaporphine or 8-hydroxyartabonatine C (1) was isolated, together with the known 1,2,3-trimethoxy-4,5-dioxo-6a,7-dehydroaporphine (ouregidione, 2). Their structures were elucidated by a combination of spectral methods; mainly 2D NMR; IR and MS. Compounds 1 and ...

objectives colloidal drug delivery system, solid lipid nanoparticles (slns), helps to increase the solubility of the drug and its oral bioavailability. methods tamoxifen (tam) as a nonsteroidalantiestrogen drug was formulated in sln and an in vitro study was conducted to determine the cytotoxicity effect of tam-loaded slns on human breast cancer cell lines mcf-7 (estrogen receptor-positive) and...

Cathepsin D trafficking is altered in cancer cells, leading to increased secretion of the pro-enzyme, which can be reinternalized by the same cancer cells and by stromal cells. We studied pro-cathepsin D endocytosis in two human breast cancer cell lines (MDA-MB231, MCF-7) and in human normal fibroblasts. Pro-enzyme uptake was studied indirectly through immunofluorescence analysis of anti-pro-ca...

This study aims at characterization of the anti-cancer active compounds separated from stems and branches Sambucus williamsii var. coreana Nakai (Caprifoliaceae). Bioactivity-guided fractionation ethanol extracts S. was isolated three triterpenoid compounds. fractions showed superior growth inhibitory activity against cancer cells (HCT116, A549 MDA-MB231). Active fraction analyzed led to identi...

BACKGROUND Since aggressive cancer cells highly express the CD44 receptor compared to normal cells, hyaluronic acid (HA) can be used for CD44 targeting molecule. Since glutathione (GSH) level is normally elevated in the intracellular compartment and in the tumor cell, the fact that disulfide bond can be cleaved by GSH is widely used for intracellular drug delivery. METHODS HA was connected wi...

The rubber tree (Hevea brasiliensis) extracts are becoming increasingly visible in pharmaceutical and therapeutical research. The present study is aimed at examining the specific anti-proliferation property of H. brasiliensis latex B-serum sub-fractions against human breast cancer epithelial cell lines MCF-7 and MDA-MB231. The results showed that the latex whole B-serum and DBP sub-fraction exe...

Background: Wogonin as a flavonoid compound is known for its anticancer effect through growth control, differentiation, and apoptosis. This study investigates the possible activity of wogonin in inducing cell death breast tumors MDA-MB231. Materials Methods: The level proliferation was evaluated by MTT assay. Cycle analysis apoptotic rate were assessed flow cytometry. mRNA Bax, Bcl-2, p53, surv...