Bronchiolitis obliterans syndrome (BOS) is a severe complication after lung transplantation (LTX). In a retrospective cohort study 12 stable healthy recipients (non-BOS) and eight patients with BOS were enrolled after LTX and matrix metalloproteinases (MMP)-9, TIMP-1 and cell characteristics in bronchoalveolar lavage (BAL) samples (n = 145) were analysed. BALs from patients with BOS were furthe...

Matrix metalloproteinases (MMPs) are a heterogeneous family of endopeptidases that play role in many physiological functions, including the immune response. An imbalance between activity MMPs and their tissue inhibitors (TIMPs) has been proposed pathophysiology different autoimmune disorders. We aimed to assess plasmatic levels MMP-2, MMP-9, TIMP-1 -2 patients with chronic inflammatory demyelin...

results genotype frequencies of g/a in fertile and infertile men were significantly different (χ2 = 4.16, df = 1, p = 0.041). genotype frequencies of g/g and a/ain fertile and infertile men were not significantly different (χ2 = 3.32, df = 1, p = 0.068 and χ2 = 0.521, df = 1, p = 0.47, respectively). the risk of infertility was 1.43 folds higher in individuals with the a/a genotype compared to ...

Shen et al. assessed the impact of matrix metalloproteinases (MMP)-2 and -9 as well collagen synthesis degradation on in stent stenosis.1 In an animal study, they implanted Z-stents into common iliac arteries 60 Guangxi Bama mini-pigs. The affected artery segments were after 10 different time intervals between six hours 336 days, leading to appropriate overview endothelial changes related forei...

The variants of angiotensin converting enzyme (ACE) and matrix metalloproteinases (MMPs) genes might be involved in the pathogenesis of end stage renal disease (ESRD) and hypertension. We studied the ACE insertion/deletion (I/D) and MMP-7 A-181G variants in 99 unrelated ESRD patients and 117 individuals without renal complications from Western Iran with Kurdish ethnic background. The frequency ...

objective: gelatinases are a large group of proteolytic enzymes that belong to the matrix metalloproteinases (mmps). mmps are a broad family of peptidases, which proteolyse the extracellular matrix and have an important role in inflammation. verapamil is a calcium channel blocker extensively used in the treatment of numerous cardiovascular diseases such as arrhythmia and hypertension. the anti-...

Background: Leukemia is a malignant proliferative disorder of the hematopoietic cells. The important role of angiogenesis in leukemia has been reported by several studies. Matrix metalloproteinases (MMPs) are a large group of endopeptidases which degredate the extracellular matrix and play an important role in angiogenesis. Objective: The present study was conducted to evaluate the patterns of ...

Matrix metalloproteinases (MMPs) function in the remodeling of the extracellular matrix that is integral for many normal and pathological processes. The tissue inhibitor of metalloproteinases family, including tissue inhibitor of metalloproteinases-2 (TIMP-2), regulates the activity of these multifunctional metalloproteinases. TIMP family members are proteinase inhibitors that contain six conse...

PURPOSE The matrix metalloproteinases (MMPs) are a family of proteolytic enzymes involved in tumor invasion; several individual members of which have been implicated in tumor prognosis. These enzymes and their physiologic inhibitors, the tissue inhibitors of matrix metalloproteinases (TIMPs), act in a coordinated manner to form an integrated system. Therefore, to understand their role in tumor ...

BACKGROUND Oral submucous fibrosis (OSF), a potentially malignant oral lesion, is a form of pathological fibrosis affecting the oral mucosa. It results from an imbalance in equilibrium of the normal process of synthesis and degradation of extra cellular matrix. Matrix metalloproteinases and its inhibitors play important role in remodeling of the extra cellular matrix which are important in prog...