Calcium (Ca(2+)) release from reticular stores is a vital regulatory signal in eukaryotes. Recent structural data on large NH(2)-terminal regions of IP(3)Rs and RyRs and their tetrameric arrangement in the full-length context reveal striking mechanistic similarities in Ca(2+) release channel function. A common ancestor found in unicellular genomes underscores the fundamentality of these element...

Abstract This article aims to provide an explication of the doctrine monarchy Father. A precisification is made within building-fundamentality framework provided by Karen Bennett, which enables a further clarification central elements be and important objection against it answered.

In accounting for the objects and properties of the manifest world, issues include the fundamentality, causal efficacy and ontological robustness of the dispositional (powers, potentials, capacities) versus the non-dispositional (categorical, qualitative). Concerning fundamentality, the available options seem to be that: (i) dispositional and categorical properties are different kinds, both fun...

Abstract This is a contribution to the controversy which of individual or collective intentionality more fundamental. I call it fundamentality-question. In first step, argue that really two questions. One about sense and one reference. The is: Can grasp understand concept and, correspondingly, individuality, on hand, without grasping understanding collectivity, other? second corresponding refer...

The concept of ${mathscr{F}}_{st}$-fundamentality is introduced in uniform spaces, generated by some filter ${mathscr{F}}$. Its equivalence to the concept of ${mathscr{F}}$-convergence in uniform spaces is proved. This convergence generalizes many kinds of convergence, including the well-known statistical convergence.

Many philosophical theories make comparisons between objects, events, states of affairs, worlds, or systems, and many such theories deliver plausible verdicts only if some of the elements they compare are ranked as ‘best.’ When the relevant ordering does not have such ‘best’ or ‘tied for best’ elements the theory wrongly falls silent or gives badly counterintuitive results. I call these limit a...

Let S be the unit sphere in R and let 〈 · , · 〉 denote the usual inner product in R. We characterize those functions K in L([−1, 1]), p ≥ 1, for which the associated set of zonal functions {x ∈ S → K(〈x, y〉) : y ∈ S } is fundamental in L(S). We then study fundamentality of sets generated by either spherical convolution or spherical shifting, thus providing methods of construction of fundamental...