نتایج جستجو برای: maspin gene

تعداد نتایج: 1141580  

2016
Wen-Shu Chen Liang-Chih Liu Chia-Jui Yen Yun-Ju Chen Jhen-Yu Chen Chien-Yi Ho Shu-Hui Liu Ching-Chow Chen Wei-Chien Huang

Maspin is a tumor suppressor that stimulates apoptosis and inhibits metastasis in various cancer types, including hepatocellular carcinoma (HCC). Our previous study has demonstrated that HBx induced microRNA-7, 103, 107, and 21 expressions to suppress maspin expression, leading to metastasis, chemoresistance, and poor prognosis in HCC patients. However, it remains unclear how HBx elicits these ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2005
Stephen S C Chim Yu K Tong Rossa W K Chiu Tze K Lau Tse N Leung Lisa Y S Chan Cees B M Oudejans Chunming Ding Y M Dennis Lo

The discovery of fetal DNA in the plasma of pregnant women has opened up new approaches for noninvasive prenatal diagnosis and monitoring. Up to now, the lack of a fetal DNA marker that can be universally detected in maternal plasma has limited the clinical application of this technology. We hypothesized that epigenetic differences between the placenta and maternal blood cells could be used for...

Journal: :Anticancer Research 2021

Background/Aim: Maspin has tumor-suppressor functions; however, its prognostic value in patients with oral squamous cell carcinoma (OSCC) remains unknown. We aimed to assess the importance of subcellular localization maspin OSCC. Patients and Methods: Eighty resected specimens were analyzed by immunohistochemistry. Cytoplasmic-only expression observed >10% tumor was defined as maspin-positiv...

2013
Sijana H. Dzinic Alexander Kaplun Xiaohua Li Margarida Bernardo Yonghong Meng Ivory Dean David Krass Paul Stemmer Namhee Shin Fulvio Lonardo Shijie Sheng

Maspin, a multifaceted tumor suppressor, belongs to the serine protease inhibitor superfamily, but only inhibits serine protease-like enzymes such as histone deacetylase 1 (HDAC1). Maspin is specifically expressed in epithelial cells and it is differentially regulated during tumor progression. A new emerging consensus suggests that a shift in maspin subcellular localization from the nucleus to ...

Journal: :The Journal of biological chemistry 2002
Rosemary Bass Ana-María Moreno Fernández Vincent Ellis

Maspin is a member of the serpin family of protease inhibitors and is a tumor suppressor gene acting at the level of tumor invasion and metastasis. This in vivo activity correlates with the ability of maspin to inhibit cell migration in vitro. This behavior suggests that maspin inhibits matrix-degrading proteases, such as those of the plasminogen activation system, in a similar manner to the se...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2002
Anil K Sood Mavis S Fletcher Lynn M Gruman Jeremy E Coffin Sarvenaz Jabbari Zhila Khalkhali-Ellis Nancy Arbour Elisabeth A Seftor Mary J C Hendrix

Maspin is a noninhibitory member of the serpin family that is down-regulated in breast carcinoma but overexpressed in pancreatic carcinoma. There are no published data regarding the role of maspin in ovarian carcinoma, which is the focus of the present study. Ovarian cell lines (normal and cancer) and tumors (80 invasive, 14 benign, and 10 low malignant potential) were evaluated for maspin expr...

Journal: :Cancer research 2006
Shuping Yin Jaron Lockett Yonghong Meng Hector Biliran Grant E Blouse Xiaohua Li Neelima Reddy Zimin Zhao Xinli Lin John Anagli Michael L Cher Shijie Sheng

It is well documented that tumor suppressive maspin inhibits tumor cell invasion and extracellular matrix remodeling. Maspin is a cytosolic, cell surface-associated, and secreted protein in the serine protease inhibitor superfamily. Although several molecules have been identified as candidate intracellular maspin targets, the extracellular maspin target(s) remains elusive. Although maspin does ...

Journal: :The Journal of biological chemistry 2009
Rosemary Bass Laura Wagstaff Lorna Ravenhill Vincent Ellis

Maspin is a serpin that has multiple effects on cell behavior, including inhibition of migration. How maspin mediates these diverse effects remains unclear, as it is devoid of protease inhibitory activity. We have previously shown that maspin rapidly inhibits the migration of vascular smooth muscle cells (VSMC), suggesting the involvement of direct interactions with cell surface proteins. Here,...

Journal: :International journal of molecular medicine 2008
Hye-Lim Jang Eunsook Nam Kon Ho Lee Seonyong Yeom Hee Jung Son Chaehwa Park

Maspin is a tumor suppressor protein that stimulates apoptosis and inhibits motility, invasion and cancer metastasis. We report on a previously uncharacterized Pro/Ser (C to T) polymorphism at amino acid 176 of the human maspin protein. We analyzed the maspin mutation in 17 cancer cell lines and 36 cancer tissues. Association of polymorphic variants on apoptosis, colony formation and in vivo tu...

Journal: :Oncology reports 2007
Hang Wun Raymond Li See Wai Leung Chun Sing Samuel Chan May Mei-Yung Yu Yick Fu Wong

Maspin is a member of the serpin family, whose expression is altered in neoplasia and malignancies of many tissues. Underexpression of maspin has been reported in breast and prostatic cancers, but in some cancers such as ovarian, colorectal and pancreatic carcinoma, it was found to be up-regulated. This study aimed at demonstrating the expression of maspin in human endometrial tissue and search...

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