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This paper presents a review on the genetics of A. annua as an important plant species for the treatment of malaria. A short history on the discovery of the plant is discussed. Furthermore, a clear description of the characteristics of A. annua is presented as the plant’s chemistry, mechanism of action and efficacy are thoroughly discussed. Many cytogenetic studies on A. annua focusing on the p...

PURPOSE To investigate the ability of a commercial extract from the medicinal plant Artemisia annua to modulate production of the cytokine, tumor necrosis factor-alpha (TNF-α), and the cyclooxygenase (COX) inflammatory marker, prostaglandin E2 (PGE2) in activated neutrophils. METHODS Neutrophils were harvested from rat whole blood and cultured in the presence of plant extract or control sampl...

Objective: This review intends to motivate and encourage researchers to explore new alternatives to treat different diseases with Artemisia annua L., an important plant of traditional Chinese pharmacopoeia that has been used for more than 2.000 years in the treatment of different diseases, mainly malaria. Methods: Data include currently available information about A. annua, its origin, traditio...

Endophytic actinobacteria colonize internal tissues of their host plants and are considered as a rich and reliable source of diverse species and functional microorganisms. In this study, endophytic actinobacterial strain YIM 63111 was isolated from surface-sterilized tissue of the medicinal plant Artemisia annua. We identified strain YIM 63111 as a member of the genus Pseudonocardia. A. annua s...

Artemisia annua is widely studied for its ability to accumulate the antimalarial sesquiterpenoid artemisinin. In addition to producing a variety of sesquiterpenoids, A. annua also accumulates mono-, di-, and triterpenoids, the majority of which are produced in the glandular trichomes. A. annua also has filamentous trichomes on its aerial parts, but little is known of their biosynthesis potentia...

Artemisinin is extracted from a traditional Chinese medicinal herb Artemisia annua L., which is regarded as the most efficient drug against malaria in the world. In recent years, attention has been paid to increase the artemisinin content through transgenic methods because of the low content of artemisinin in wild plants. In this article, three functional artemisinin-related genes namely dxr, c...

Artemisia annua is used as a source of artemisinin, a potent therapeutic agent used for the treatment of infectious diseases, chiefly malaria. However, the low concentration (from 0.01 to 1.4% of dried leaf matter) of artemisinin in the plant obtained with the traditional cropping system makes it a relatively expensive drug, especially in developing countries. Considering that artemisinin and s...

The plant Artemisia annua L. (Asteraceae) is listed in the Chinese pharmacopoeia as a remedy for various fevers including malaria, and contains the well-established antimalarial compound artemisinin. In this study, a hybrid form of A. annua was successfully cultivated in Central Africa. The aerial parts of the plant contained 0.63-0.70% artemisinin per dry weight, and approximately 40% of this ...

Artemisia annua belongs to the asteraceae family, indigenous to the mild climate of Asia. The aim of this study was to overview its anti-malarial properties, immunosuppressive properties, anti-inflammatory properties and anti-cancer properties. This systematic review was carried out by searching studies in PubMed, Medline, Web of Science, and IranMedex databases. The initial search strategy ide...