Escherichia coli nitroreductase (NTR) may convert the prodrug CB1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide) into a bifunctional alkylating agent, which may lead to DNA crosslinks and the apoptosis of cancer cells. NTR/CB1954 has been demonstrated to be an effective gene therapy in cancer cells. The present study examined whether the NTR/CB1954 suicide gene system had cytotoxic effects on HeLa...

Speakers include: Irit Akirav (Haifa); Antonio Armario (Spain); Eyal Asor (Haifa-Technion); (Edi Barkai (Haifa); Katharina Braun (Germany); Patrizia Campolongo (Italy); Alon Chen (Israel); Dori Derdikman (Haifa-Technion); Aline Desmedt (France); Guillaume Ferreira (France); Inna Gaisler-Salomon (Haifa); Uwe Heinemann (Germany); James Herman (USA); Andrew Holmes (USA); Megan Holmes (United Kingd...

The feasibility of ablating differentiated adipocytes and the mechanism of cell ablation with a suitable prodrug activating system is described. The system is based on the use of E. coli nitroreductase (NTR) enzyme that activates certain nitro compounds, such as the antitumor drug CB1954, into cytotoxic DNA interstrand cross-linking agents. Differentiated preadipocyte cells (3T3L1) transfected ...

urban expansion and agriculture intensification are relevant drivers in land degradation (ld)processes in europe due to net loss of land, soil sealing, landscape fragmentation and other negative effects on the environment. this paper explores changes (or “trajectories” of change) in land use and cover (lulc) and their relationship with the consumption of soils in emilia-romagna (northern italy)...

After the collapse of Ottoman Empire and sharing its properties among modern colonial countries, state Turkey was established by Mustafa Ataturk. By all concepts, it is very far from commitment to principles legislation Islam with those who seek apply Western civilization, including without scrutiny, in what benefits country people or does not benefit, trying keep Muslim youth away morals their...