The microgravity experienced during space flight induces physiological changes that affect astronauts' health and performance. Simulations such as prolonged bed rest can mimic some of these changes and provide study conditions that are more accessible than during space flight itself. Previous studies, including several long and short-term bed-rest campaigns supported by ESA, have yielded signif...

BACKGROUND The associations between nitrogen metabolism and bone turnover during bed rest are still not completely understood. METHODS We measured nitrogen balance (nitrogen intake minus urinary nitrogen excretion) and biochemical metabolic markers of calcium and bone turnover in six males before head-down tilt bed rest (baseline), during 2, 10, and 14 weeks of immobilization, and after reamb...

One of the key objectives of oncology first-in-human trials has often been to establish the maximum tolerated dose (MTD). However, targeted therapies might not exhibit dose-limiting toxicities (DLT) at doses significantly higher than sufficiently active doses, and there is frequently a limited ability to objectively quantify adverse events. Thus, while MTD-based determination of recommended pha...

OBJECTIVES To examine the characteristics of nailfold capillary changes in patients with glaucoma and to analyze their possible relationship to other clinical characteristics of glaucoma. METHODS One hundred eight glaucoma patients and 38 control patients were enrolled in the study. Eighty-six patients were classified as having normal tension glaucoma and 22 patients as having primary open-an...

PURPOSE Tumor cells can metastasize by entering existing vessels or new vessels actively recruited into the primary tumor. Invasion of the lymphatics and blood vessels in the periphery of the tumor seems to be a prerequisite step in the metastatic process. The aim of this study was to correlate peripheral lymphatic vessel infiltration (PLI) and peripheral blood vessel infiltration (PVI) in a co...

Abstract The Cretaceous-Paleogene (K-Pg) contact interval is constrained by vertebrate fossil sites at seven in the Tornillo Group and lies within an 80–100-m stratigraphic section between top of Javelina Formation base “log jam sandstone” marker bed Black Peaks Formation. In western exposures this interval, highest occurrence situ dinosaur specimens lowest Paleocene mammal are separated unusua...

Background: Specimen radiography plays an essential role in breast pathology, the identification and correlation of microcalcifications, location biopsy site abnormal tissue.1 Aim: To examine characteristics specimens that had underwent specimen radiography. Method: Over a six-month period, X-ray during macroscopic assessment were identified. Parameters included type, size, diagnosis, margin st...

small supernumerary marker chromosomes (ssmc) are still a major problem in clinical cytogenetics as they cannot be identified or characterized unambiguously by conventional cytogenetics alone. on the other hand, and perhaps more importantly in prenatal settings, there is a challenging situation for counseling how to predict the risk for an abnormal phenotype, especially in cases with a de novo ...

The theory of bulk orbital magnetization has been formulated both in reciprocal space based on Berry curvature and related quantities, real terms the spatial average a quantum mechanical local marker. Here we consider three-dimensional antiferromagnetic material having vanishing but nonzero surface magnetization. We ask whether surface-normal component is well defined, if so, how to compute it....