UNLABELLED We introduce TOPS+ strings, a highly abstract string-based model of protein topology that permits efficient computation of structure comparison, and can optionally represent ligand information. In this model, we consider loops as secondary structure elements (SSEs) as well as helices and strands; in addition we represent ligands as first class objects. Interactions between SSEs and b...

deconSTRUCT webserver offers an interface to a protein database search engine, usable for a general purpose detection of similar protein (sub)structures. Initially, it deconstructs the query structure into its secondary structure elements (SSEs) and reassembles the match to the target by requiring a (tunable) degree of similarity in the direction and sequential order of SSEs. Hierarchical organ...

We demonstrate that a recent dike intrusion probably triggered a slow fault-slip event (SSE) on Kilauea volcano's mobile south flank. Our analysis combined models of Advanced Land Observing Satellite interferometric dike-intrusion displacement maps with continuous Global Positioning System (GPS) displacement vectors to show that deformation nearly identical to four previous SSEs at Kilauea occu...

This study investigated the activity and distribution of low-frequency earthquakes (LFEs) accompanying the very low frequency earthquakes (VLFEs) in the central and southern Ryukyu Trench. This investigation was based on shortperiod seismometer waveforms obtained by the Japan Meteorological Agency from April 2004 to December 2015. The LFEs were detected using the Envelope Correlation Method, an...

Slow slip events (SSEs) detected on the Cascadia Subduction Zone interface at 30–50 km depth imply a release of accumulated strain. However, studies interseismic deformation in typically find coupling upper 30 interface, which is generally accepted as defining seismogenic zone. Estimates using net velocities (including SSE effects) and restricting to shallow may underestimate deficit accumulati...

BACKGROUND In a phase III trial in patients with castration-resistant prostate cancer (CRPC) and bone metastases, denosumab was superior to zoledronic acid in reducing skeletal-related events (SREs; radiation to bone, pathologic fracture, surgery to bone, or spinal cord compression). This study reassessed the efficacy of denosumab using symptomatic skeletal events (SSEs) as a prespecified explo...

OBJECTIVE To determine if interactive computerized patient education, skin self-examination (SSE) tutorials, and telecommunication reminders could be combined to increase patient performance of SSEs, increase confidence in ability to identify melanoma, and influence individual melanoma risk perception. DESIGN A total of 132 adult participants from our dermatology clinics were enrolled in an int...

We examine the nonlinear one-step forward-looking model, in which the current state is a function of the (subjective) expected value of a nonlinear function of the state next period. Stationary Markov Sunspot Equilibria (SSEs) are known to exist near an indeterminate steady state, i.e. when the derivative of the function at the steady state is bigger than one in absolute value. We show that the...

The problem of comparison of structural similarity has been complex and computationally expensive. The first step to solve comparison of structural similarity in 3D structure databases is to develop fast methods for structural similarity. Therefore, we propose a new method of comparing structural similarity in protein structure databases by using topological patterns of proteins. In our approac...

Abstract Silicon (Si)‐based solid‐state batteries (Si‐SSBs) are attracting tremendous attention because of their high energy density and unprecedented safety, making them become promising candidates for next‐generation storage systems. Nevertheless, the commercialization Si‐SSBs is significantly impeded by enormous challenges including large volume variation, severe interfacial problems, elusiv...