نتایج جستجو برای: manufactured ha1

تعداد نتایج: 42224  

2010
Wei Hu

Hemagglutinin (HA) of influenza viruses is a cylindrically shaped homotrimer, where each monomer comprises two disulfide-linked subdomains HA1 and HA2. Influenza infection is initiated by binding of HA1 to its host cell receptors and followed by the fusion between viral and host endosomal membranes mediated by HA2. Human influenza viruses preferentially bind to sialic acid that is linked to gal...

Journal: :Vaccine 2009
S Spitsin V Andrianov N Pogrebnyak Y Smirnov N Borisjuk C Portocarrero V Veguilla H Koprowski M Golovkin

Polypeptide variants of the HA1 antigenic domain of the H5N1 avian influenza virus hemagglutinin (HA) molecule were produced in plants using transient and stable expression systems and fused with His/c-myc tags or with mouse or human Fc antibody fragments. The resulting peptides were purified and used for intramuscular immunization of mice. While the recombinant HA1 variants induced a significa...

زمینه و اهداف: ویروس H5N1  ممکن است قابلیت انتقال بین انسان ها را بدست آورد. بنابراین امکان وقوع یک بیماری همه گیر وجود دارد. پروتئین HA1  نقش اصلی را در اتصال ویروس به سلول هدف بازی می کند و پاسخ های آنتی بادی خنثی کننده عمدتاً علیه این ناحیه است. باسیلوس سوبتیلیس میزبانی بدون اندوتوکسین جهت بیان وترشح پروتئین های هترولوگ واجد فعالیت ایمونولوژیک شناخته شده است. اگر چه این باکتری قادر به تولید پ...

Journal: :The Journal of Experimental Medicine 1987
K G Gould H Scotney A R Townsend J Bastin G G Brownlee

We have constructed two chimeric influenza hemagglutinin (HA) genes in which the HA1 and HA2 subunits of the HA molecule have been interchanged between influenza A/PR/8/34 (H1 subtype) and A/NT/60/68 (H3 subtype). These genes were used to construct recombinant vaccinia viruses that expressed intact chimeric HA. These recombinant viruses were used to test whether murine CTL recognize antigenic d...

Journal: :Gene 2008
Yoshiyuki Suzuki

It has been proposed that antigenic evolution of hemagglutinin 1 (HA1) for H3N2 human influenza A virus was punctuated. In the population genetic analysis, however, it was controversial whether positive selection operated on HA1 in a punctuated manner for the branches of the phylogenetic tree where transitions to new antigenic clusters occurred (C branches), or continuously. In the molecular ev...

2017
Cesáreo Trueba Vasavilbaso Carlos David Rosas Bello Erla Medina López Maria Pilar Coronel Granado José Mario Navarrete Álvarez Cesáreo Angel Trueba Davalillo Félix Isaac Gil Orbezo

PURPOSE To assess the effectiveness of viscosupplementation or platelet-rich plasma (PRP), compared to standard care, for pain relief after knee arthroscopic debridement in patients with meniscal pathology and osteoarthritis (OA), under normal clinical practice conditions. PATIENTS AND METHODS We conducted a prospective, randomized, evaluator-blind, pilot study. After arthroscopy, patients we...

Journal: :The Journal of Experimental Medicine 1994
F Temoltzin-Palacios D B Thomas

The regions of antigenic variation in influenza hemagglutinin (HA) are located on surface-accessible regions in the three-dimensional structure of the HA1 monomer. The aim of this study was to establish whether a novel variant virus, IMUT4, in which we had mutated specific amino acid residues (HA1 63, 144, 158, and 193) in these regions, previously shown to be immunodominant for CBA/Ca mice, wo...

2012
Xiaochen Liu Minzhi Zhao Jingxiong Lu Jian Ma Jie Wei Shicheng Wei

INTRODUCTION Hydroxyapatite (HA) is the principal inorganic constituent of human bone. Due to its good biocompatibility and osteoconductivity, all kinds of HA particles were prepared by different methods. Numerous reports demonstrated that the properties of HA affected its biological effects. METHODS Two kinds of nanohydroxyapatite with different sizes and crystallinities were obtained via a ...

2006
Yun-Huei Tzeng Feng-Chi Chen Chiuan-Jung Chen Trees-Juen Chuang

Background: Avian influenza A has been a major threat to worldwide public health. The evolutionary patterns of the pathogenic viruses between humans and birds are essential to effective monitoring of disease propagation. In this study, we focused on finding an appropriate evolutionary measure for avian influenza A to reflect its adaptation to human hosts and outbreaks in human population. We es...

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