A series of 3-substituted-4-(5-nitro-2-furfurylidene)amino-5-mercapto-1,2,4-triazoles 3 and their Mannich bases have been synthesized. The structures of these Schiff bases and Mannich bases were confirmed on the basis of elemental analysis, H NMR and mass spectral data. The above compounds were also screened for their antifungal activity against C.albicans.

Aminomethyl derivatives of 1,5-bis(4-hydroxy-3-methoxyphenyl)penta-1,4-dien-3-one, designed as new cytotoxins, were synthesized and evaluated in terms of their cytotoxic activities. The compounds have low CC50 values in the low micromolar range against HL-60 neoplasms and HSC-2, HSC-3 and HSC-4 carcinoma cells. In general, the average CC50 values of these compounds were higher towards HGF, HPC ...

A series of new mannich base derivatives 4-(furan-2-yl(2-(furan-2-yl methylene)hydrazinyl)methyl)morpholine(1-6) were synthesized and synthesized compounds (16) were confirmed by IR, 1H NMR, 13C NMR, Mass spectral, mass spectral fragmentation and elemental analysis. Synthesized compounds (1-6) were screened for antimicrobial activity. Structural activity relationship has been discussed in this ...

BACKGROUND AND PURPOSE Tuberculosis (TB) remains a major global health threat and is now the leading cause of death from a single infectious agent worldwide. The current TB drug regimen is inadequate, and new anti-tubercular agents are urgently required to be able to successfully combat the increasing prevalence of drug-resistant TB. The purpose of this study was to investigate a piperidinol co...

Organic base-catalyzed reaction of (S)-N-tert-butanesulfinyl (3,3,3)-trifluoroacetaldimine with dialkyl malonates was found to be effective for synthesis of both (S,S(S)) and (R,S(S)) β-aminomalonates in high yield with good to excellent diastereoselectivity (76-98% de). The products of this Mannich reaction provide direct access to β-trifluoromethyl-β-alanine of either (R) or (S) absolute conf...

An efficient one-pot nitro-Mannich/hydroamination cascade reaction for the synthesis of substituted pyrrolidines bearing three stereocentres is reported. Proceeding under the control of a combination of base and gold(I) catalysts, the cascade reaction affords the pyrrolidine products in high yields with good to excellent diastereoselectivities.

A highly selective and sensitive phenanthroimidazole tagged Mannich base type dizinc(II) fluorescent probe (R-Zn²⁺) has been developed for the pyrophosphate ion (PPi) with a very low limit of detection (LOD) of 0.25 ppm; this also assesses PPi from DNA polymerization chain reaction (PCR).