The size of conformational ensembles required for regular coverage of the conformational space of druglike molecules was examined. Using the conformer generation program Omega, the number of regularly distributed conformers (NRC) of flexible compounds was determined as a function of the root-mean-square deviation (RMSD) resolution of coverage. A regression equation was developed predicting the ...

A set of perception experiments, using reiterant speech, were designed to carry out a diagnostic of the segmentation / hierarchisation linguistic function of prosody. The prosodic parameters of F0, syllabic duration and intensity of the stimuli used during this experiment were extracted. Several dissimilarity measures (Correlation, root-mean-square distance and mutual information) were used to ...

In 2008, women comprised 46.5 percent of the U.S. labor force, and occupied nearly 51 percent of all managerial and professional jobs, yet women holding the titles of chairman, chief executive officer (CEO), chief operating officer (COO), and executive vice-president (EVP) remained at about seven percent of the population of U.S. executives, according to the non-profit research group, Catalyst....

Since the introduction of the Public Finance Management Act (PFMA) in 1999, the Municipal Finance Management Act (MFMA) in 2003 and the Public Sector Risk Management Framework (PSRMF) in 2010, municipalities had to start focusing on more efficient risk management as part of operational activities. Information for the study was obtained from two groups of officials employed at the Sedibeng Distr...