aza heterocyclic compounds are major interest for organic chemists because of their mainly pharmacological activities and clinical applications such as antianxiety, antitumor, anticonvulsant, cardiotonic and vasorelaxant. this contribution describes an electrochemical approach for the preparation of nanosized particles of phthalazine in high yields and very short reaction time. the method is ba...

The reaction of phenyl isoselenocyanate (1a) with malononitrile (= propanedinitrile) in DMF in the presence of Et3N leads to the intermediate ketene N,Se-hemiacetal 6a, which can be trapped with bromoacetonitrile or a-halogenated ketones 12a and 12b (Scheme 3). The products are [(alkylseleno)(phenylamino)methylene]malononitriles 10 and 13, which are obtained in good yield. In the case of the (2...

An efficient three-component reaction of indole, aldehyde, and malononitrile in water catalyzed by a copper(II) sulfonato Salen complex afforded 3-indole derivatives in good to excellent yields up to 97%.

The covalent, surface functionalization of graphene oxide with the malononitrile anion has been demonstrated. Once installed, these surface-bound "molecular lynchpins" can be chemically modified to increase the solubility of the graphene derivative in either organic or aqueous environments.

A three-component cascade reaction of salicylaldehyde, malononitrile/cyanoacetate and nitromethane catalysed by chiral tertiary amino-thioureas was developed, which leads to the production of highly functionalized 2-amino-4H-chromenes in good yields with good to excellent enantioselectivities.

The title compound, C(19)H(26)O(3), was synthesized directly from the condensation of 5,5-dimethyl-cyclo-hexane-1,3-dione with malononitrile catalysed by palladium chloride: there are two molecules in the asymmetric unit.

In the title mol-ecule, C(17)H(12)N(2)O, the dihedral angle between the two benzene rings is 84.98 (10)°. The dicyano-ethyl-ene group is coplanar with the benzene ring to which it is bonded. No classic hydrogen bonds were found in the crystal.

As a starting reagent in organic synthesis, malononitr i le-dicyanomethylene has an established posit ion because of its reactivity in the addi t ion, self addi t ion, and condensation reactions leading to various carbocyclic and heterocyclic systems [1]. The a im of our work is to investigate the reaction path of malononitrile dimerizat ion and the structure of the reaction product using q u a...