Elevated prolactin levels seem to be associated with impaired sexuality. The clinical significance of macroprolactinemia, associated with the predominance of high molecular mass circulating forms of prolactin, is still poorly understood. This study was aimed at investigating sexual function in young women with macroprolactinemia. The study enrolled 14 young women with macroprolactinemia, 14 wit...

Reply by Authors. We appreciate the interest of Delgrange in our study. MacRoprolactinemia is a clinically and biologically heterogeneous condition. Leslie et al studied 55 women with typical hyperprolactinemia and reported that symptoms of typical hyperprolactinemia were uncommon. Vallette-Kasic et al examined 106 patients with macroprolactinemia and found that 61% had normal menstruation and ...

UNLABELLED BACKGROUND The so called "big-big" prolactin (Prl), also known as macroprolactin is formed by Prl-immunoglobulin (Prl-IgG) complexes and may cause elevation of serum Prl concentrations measured by standard assays, potentially leading to unnecessary investigations and/or treatment. In our study, we have endeavoured to assess the prevalence of macroprolactinaemia in euthyroid, regul...

one at the concentration of 7 pg/mg. This result was not challenged by the athlete. Nandrolone has also been identified by this laboratory in the hair of bodybuilders, in concentrations of 1–7 pg/mg (8 ). NA and noretiocholanolone were not detected in any hair. The sensitive, specific, and reproducible method developed appears to be suitable for the detection and quantification of 19-norsteroid...