Cryo-electron microscopy (cryo-EM) of frozen-hydrated preparations of isolated macromolecular complexes is the method of choice to obtain the structure of complexes that cannot be easily studied by other experimental methods due to their flexibility or large size. An increasing number of macromolecular structures are currently being obtained at subnanometer resolution but the interpretation of ...

Evidence has been presented for a metabolic multienzyme complex, the purinosome, that participates in de novo purine biosynthesis to form clusters in the cytoplasm of living cells under purine-depleted conditions. Here we identified, using fluorescent live cell imaging, that a microtubule network appears to physically control the spatial distribution of purinosomes in the cytoplasm. Application...

Macromolecular information transfer can be defined as the process by which a coded monomer sequence is communicated from one macromolecule to another. In such process, kept identical, transformed into complementary or even translated different molecular language. Such mechanisms are crucial in biology and take place DNA→DNA replication, DNA→RNA transcription RNA→protein translation. fact, there...

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTBioinspired Macromolecular MaterialsMatthew J. Webber*Matthew WebberUniversity of Notre Dame, Department Chemical & Biomolecular Engineering, Indiana 46556, United States*Email: [email protected]More by Matthew Webberhttp://orcid.org/0000-0003-3111-6228, Neha P. KamatNeha KamatNorthwestern University, Biomedical Evanston, Illinois 60208, StatesMore Kama...