نتایج جستجو برای: lymphopenia

تعداد نتایج: 2617  

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2014
James W Welsh Steven N Seyedin Maria Angelica Cortez Amit Maity Stephen M Hahn

Radiotherapy induces galectin-1 (Gal-1) secretion by tumors, which induces CD8(+) T-cell apoptosis and lymphopenia. These effects are substantially decreased by Gal-1 shRNA. Inhibition of Gal-1 may be an effective strategy for overcoming radiation-induced lymphopenia, which may improve clinical outcomes.

2010
Nadera J. Sweiss Rafah Salloum Seema Ghandi Maria-Luisa Alegre Ray Sawaqed Maria Badaracco Kenneth Pursell David Pitrak Robert P. Baughman David R. Moller Joe G. N. Garcia Timothy B. Niewold

BACKGROUND Sarcoidosis is a poorly understood chronic inflammatory condition. Infiltration of affected organs by lymphocytes is characteristic of sarcoidosis, however previous reports suggest that circulating lymphocyte counts are low in some patients with the disease. The goal of this study was to evaluate lymphocyte subsets in peripheral blood in a cohort of sarcoidosis patients to determine ...

Journal: :Cancer research 2009
Isabelle Ray-Coquard Claire Cropet Martine Van Glabbeke Catherine Sebban Axel Le Cesne Ian Judson Olivier Tredan Jaap Verweij Pierre Biron Inthidar Labidi Jean-Paul Guastalla Thomas Bachelot David Perol Sylvie Chabaud Pancras C W Hogendoorn Philippe Cassier Armelle Dufresne Jean-Yves Blay

Lymphopenia is frequent in advanced cancers and predicts the toxicity of chemotherapy. Its effect on relapse and survival is uncertain. Its prognostic value for survival was analyzed in three databases of previously reported prospective multicenter studies: (a) FEC chemotherapy in metastatic breast carcinoma; (b) CYVADIC in advanced soft tissue sarcoma (European Organization for Research and Tr...

Journal: :Stroke 2016
Vanessa H Brait Gema Tarrasón Amadeu Gavaldà Núria Godessart Anna M Planas

BACKGROUND AND PURPOSE Growing evidence supports that the immunomodulatory drug fingolimod is protective in stroke. Fingolimod binds to 4 of 5 sphingosine-1-phosphate (S1P) receptors and, among other actions, it induces lymphopenia. In this study, we investigated whether a selective S1P1 agonist is protective in experimental stroke. METHODS Drug selectivity was studied in vitro in cells overe...

Journal: :Blood 2009
Yongzhi Cui Hua Zhang Joanna Meadors Rita Poon Martin Guimond Crystal L Mackall

Lymphopenia enhances the effectiveness of adoptive immunotherapy by facilitating expansion of transferred T cells but also limits the T-cell repertoire available to mediate immune responses and, in humans, is associated with chronic immune dysfunction. Previous studies concluded that lymphopenia augments adoptive immunotherapy by diminishing Tregs and increasing homeostatic cytokines. We sought...

2017
Tetsuo Saito Ryo Toya Tomohiko Matsuyama Akiko Semba Natsuo Oya

BACKGROUND Radiation-related lymphopenia has been associated with poor patient outcome. Our aim was to identify predictors of lymphopenia after palliative radiotherapy, with a focus on dose-volume parameters. PATIENTS AND METHODS To retrospectively assess patients with various cancers who had undergone palliative radiotherapy, we delineated three organs at risk: the volume enclosed by the bod...

2017
Dolores Margarita Rodríguez Mery Elizabeth Guerrero Bárbara Marisol Maldonado Claudia Vollbracht Sandra Aracely Herrera

Background: Lymphopenia commonly occurs in cancer patients and predicts poor prognosis. It is caused by radioand chemotherapy, with malnutrition and treatment-related oxidative stress playing key roles in its pathogenesis. Tumour-related morbidity is reported to be associated with reduced plasma ascorbate, which is a key physiological antioxidant and essential factor in immune function. Method:...

Journal: :Journal of clinical pathology 1950
A J Shillitoe

Since differential blood counts are now reported in absolute numbers as well as in percentages, lymphopenia is frequently found and its significance questioned. Whitby and Britton (1946) say that the lymphocytes in the peripheral blood may be diminished in the acute stages of an infection, in conditions of exhaustion, after excessive x-ray irradiation, with vitamin deficiency, and in the termin...

Journal: :Folia Endocrinologica Japonica 1993

Journal: :Arthritis Research & Therapy 2004
Hendrik Schulze-Koops

More than 30 years ago, the occurrence of spontaneous autoimmune thyroiditis was observed in rodents that were made severely T-cell lymphopenic by neonatal thymectomy or by thymectomy at week five after birth together with concomitant low dose irradiation [1,2]. Following these reports, numerous studies have shown that manipulations that generate functional T-cell lymphopenia result in the deve...

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