We have investigated the effects of interleukin (IL)-12 (natural killer cell stimulatory factor/cytotoxic lymphocyte maturation factor) on the proliferation of murine myeloid and lymphohematopoietic progenitors in methylcellulose culture. In the presence of erythropoietin (Ep), IL-12 alone failed to support colony formation by mononuclear and enriched marrow cells of normal mice. Steel factor (...

Pathology is the gold standard for clinical diagnosis and an important bridge between work basic disciplines. Therefore, training qualified pathologists very work. It challenging to diagnose lymphohematopoietic diseases in practice since they made up a large percentage of resident doctors’ standardized there are numerous knowledge nodes associated with them. this base adopts “case-introduction”...

Graft-versus-host disease (GvHD) mediated by donor T cells recognizing host alloantigens is associated with beneficial graft-versus-tumor effects in recipients of allogeneic hematopoietic cell transplants. Since leukemias and lymphomas reside largely within the lymphohematopoietic system, we have proposed that the desired graft-versus-leukemia or graft-versus-lymphoma effect can be separated fr...

We recently developed a two-step clonal cell culture system for murine lymphohematopoietic progenitors that are capable of producing myeloid and B-lymphoid progenies and characterized their cytokine requirements. We subsequently observed that addition of interleukin-3 (IL-3) or IL-1 alpha to permissive cytokine combinations in primary culture abrogates the B-lymphoid potential but not the myelo...

Was the key dependent variable operationalized via standardized scale 100.0% or other appropriately established method? Were the conclusions justified by the data/findings? 100.0% Was (were) the sampled population(s) appropriate to the study aims/hypotheses (e.g., patient groups justified, presence or absence of nonpatient comparison group appropriate to study aims)? 90.0% Were the inclusion an...