PURPOSE Biomarkers of inflammation and hemostasis have been associated with left ventricular (LV) mass. We studied relationships of C-reactive protein (CRP), interleukin-6 (IL6), D-dimer, soluble intercellular adhesion molecule-1 (sICAM-1), plasminogen activator inhibitor 1 (PAI-1), soluble thrombomodulin (sTM), soluble tumor necrosis factor type 1 receptor (sTNFR1), von Willebrand factor (vWF)...

One mechanism linking diet, specifically the Mediterranean-style diet (DT), with cardiovascular disease prevention may be an association between a DT and left ventricular (LV) mass. However, there are little data on this relation. We hypothesized that adherence to a DT would be inversely associated with LV mass in the multiethnic population-based Northern Manhattan Study. The study included 1,9...

Objective: To assess the feasibility of using contrast enhanced colour Doppler echocardiography to determine left ventricular (LV) mass and to compare its accuracy with LV mass obtained by magnetic resonance imaging (MRI). Methods: Images were acquired in the short axis plane of the heart, derived from coronal and sagittal scout views and double oblique angulation. The LV mass was calculated by...

BACKGROUND Leukocyte telomere length (LTL) decreases over the adult life course owing to the cumulative burden of oxidative stress, inflammation, and exposure to vascular risk factors. Left ventricular (LV) mass is a biomarker of long-standing exposure to cardiovascular disease risk factors. We hypothesized that LTL is related inversely to LV mass. METHODS AND RESULTS We related LTL (measured...

We performed a prospective anatomic validation study to determine the accuracy of left ventricular (LV) mass estimates from clinical two-dimensional echocardiographic (2-D echo) studies. In 21 subjects, antemortem 2-D echo LV mass determinations were compared with anatomic LV weight by postmortem chamber dissection. Major cardiac diagnoses included anatomic LV aneurysm in four, status post aneu...

Background Hypertrophic cardiomyopathy (HCM) is the most common inheritable heart disease, characterized by marked left ventricular hypertrophy in the absence of a disease that can cause hypertrophy to such extent. Both LV ejection fraction (EF) and LV mass have proven to be prognosticators in HCM. The literature is inconsistent with respect to inor exclusion of papillary muscles (PMs) to LV-ma...

Background Remodeling of the left ventricle (LV) occurs in response to various physiological and pathophysiological conditions. The American Society of Echocardiography recommend that LV remodeling be described as the relationship between LV mass and LV wall thickness based on 1-D and 2-D measurements. Cardiac magnetic resonance (CMR) provides accurate 3-D measures of LV volumes and mass; howev...

BACKGROUND Increased left ventricular (LV) mass predicts an adverse outcome in patients with essential hypertension. The purpose of this study was to determine the relation between changes in LV mass during antihypertensive treatment and subsequent prognosis. METHODS AND RESULTS Procedures including echocardiography and 24-hour ambulatory blood pressure (BP) monitoring were performed in 430 p...

BACKGROUND Doubts remain over the use of the ECG in identifying those with increased left ventricular (LV) mass. This is especially so in young individuals, despite their high prevalence of ECG criteria for LV hypertrophy. We performed a study using cardiovascular magnetic resonance (CMR), which provides an in vivo non-invasive gold standard method of measuring LV mass, allowing accurate assess...