Sucrose density gradient analysis of the fresh sera of patients with hereditary ataxia telangiectasia, disseminated lupus, and Waldenström's macroglobulinemia revealed the presence of an immunoglobulin possessing IgM determinants but having a sedimentation coefficient of approximately 7 S. Bio-Gel chromatography of patients' sera confirmed the presence of two distinct populations of IgM. The lo...

Background It has been reported that 15-20% of parous female have experienced at least one miscarriage, while 3% of them have experienced two miscarriages. The goal of this study was to evaluate the plasma level of coagulation factors in women with a history of spontaneous abortions. MaterialsAndMethods In this case-control study, 82 women with a history of two or more abortions referred to the...

An international working group of clinicians and pathologists met in 2003 under the auspices of the International Society of Nephrology (ISN) and the Renal Pathology Society (RPS) to revise and update the 1982 and 1995 World Health Organization classification of lupus glomerulonephritis. This article compares and contrasts the ISN/RPS classification and the antecedent World Health Organization ...

Mizoribine (MZB) is an imidazole nucleoside and an immunosuppressive agent. The immunosuppressive effect of MZB has been reported to be due to the inhibition of DNA synthesis in the S phase of the cell cycle. Because of its relative lack of toxicity, during the past decade MZB has been frequently used instead of azathioprine as a component of immunosuppressive drug regimens. MZB is being used t...

Title Predominant prevalence of arterial thrombosis in Japanese patients with antiphospholipid syndrome Author(s) Fujieda, Yuichiro; Atsumi, Tatsuya; Amengual, Olga; Odani, Toshio; Otomo, Kotaro; Kato, Masaru; Oku, Kenji; Kon, Yujiro; Horita, Tetsuya; Yasuda, Shinsuke; Koike, Takao Citation Lupus, 21(14): 1506-1514 Issue Date 2012-12 Doc URL http://hdl.handle.net/2115/54013 Right The final, def...

Citation: Heiler S, Lötscher J, Kreuzaler M, Rolink J and Rolink A (2018) Prophylactic and Therapeutic Effects of Interleukin-2 (IL-2)/Anti-IL-2 Complexes in Systemic Lupus Erythematosus-Like Chronic Graft-Versus-Host Disease. Front. Immunol. 9:656. doi: 10.3389/fimmu.2018.00656 Prophylactic and Therapeutic effects of interleukin-2 (il-2)/anti-il-2 complexes in systemic lupus erythematosus-like...

The search for genetic determinants of alloimmunization in sickle cell disease transfusion recipients was based on two premises: i) that polymorphisms responsible for stronger immune and/or inflammatory responses and hemoglobin β(S) mutation were co-selected by malaria; and ii) that stronger responder status contributes to development of lupus. We found a marker of alloimmunization in the gene ...