Inhalation delivery of aerosolized antibacterials is preferred over conventional methods of delivery for targeting lung infection. The present study is concerned with the development and characterization of a novel, spray dried, aerosolized, chitosan polyelectrolyte complex (PEC) based microparticles containing antibacterials for the treatment of lung infections.Chitosan polyelectrolyte complex...

Helicobacter pylori (Hp) is one of the most common bacteria infecting humans. Recently, certain extragastric manifestations, linked to Hp infection, have been widely investigated, suggesting that Hp infection might be a 'systemic' disease. Accumulating, yet limited, evidence points to a potential association between Hp infection and lung cancer risk. Epidemiologic studies have shown that odds r...

Abstract Interferon-induced transmembrane proteins (IFITMs 1, 2 and 3) can restrict viral pathogens, but pro- anti-viral activities have been reported for coronaviruses. Here, we show that artificial overexpression of IFITMs blocks SARS-CoV-2 infection. However, endogenous IFITM expression supports efficient infection in human lung cells. Our results indicate the Spike protein interacts with hi...

Linguatula serrata is one of well-known members of Pentastomida which infects both humans and animals. The aim of this study was to evaluate the prevalence of L. serrata in mesenteric lymph nodes, livers and lungs of goats slaughtered in Tabriz area, Iran. Mesenteric lymph nodes (MLNs), livers and lungs of 280 goats slaughtered in Tabriz, North-west of Iran were investigated for nymphs of L. se...

Tuberculosis is a global health problem with total of 1.4 million cases in 2015. Over the last decade, several studies have demonstrated potential role gut-lung axis treatment tuberculosis. The exact mechanism on tuberculosis still unknown, however modulation can be performed via probiotic administration. administered probiotics are capable inducing an immunomodulating effect which helps proces...

in this study, the pathogenicity of a/ch/it/5093/1999 h7n1 which had been isolated from chicken during the outbreak in italy was assessed in chicken by experimental infection virus. ten spf chickens of four week-old were inoculated with this virus, and five chickens were inoculated with uninfected allantoic fluid. for determination of virus shedding, oropharyngeal and cloacal swabs were taken f...

Background: Stenotrophomonas maltophilia (SMA) has emerged as an important pathogen capable of causing opportunistic and nosocomial infection. We performed RNA sequencing (RNA-seq) lung tissues from mice with pulmonary SMA infection over time via aerosolized intratracheal inhalation to investigate transcription profile changes in SMA-infected lungs.

Abstract Lung alveolar macrophages (AMs) reside in the space and function as key sentinels to promote lung immune resilience. Notably, major cell target of early Mycobacterium tuberculosis (Mtb) infection, AMs provide a permissive cellular niche for rapid Mtb growth. However, mechanisms which regulate permissiveness during infection remain elusive. Here, we aimed identify intrinsic features tha...

in this paper the histopathological observation of the migratory phase of schistosome larvae (schistosomulae) in the laboratory animal were studied. the first tissue samples were taken from the skin of infected animals 30 minutes after exposure to the cercariae and continued daily up to 40 days post infection. the tissue specimens were taken from skin, liver. lung, lymph nodes, kidney, brain, b...

Background: Lophomonas blattarum is protozoan generally parasitizes in the intestinal tracts of some arthropods. It can infect adults and children with unspecific respiratory symptoms. We aimed to investigate the frequency of Lophomonas blattarum in children with respiratory symptoms in North East of Iran. Materials and Methods: One hundred fifty-six children with respiratory symptoms were inv...