aims: the backbone of treatment in advanced non-small cell lung cancer is platinum-based doublet chemotherapy. we intended to compare the effectiveness of two commonly used regimens in real world practice. methods: this single institute, parallel comparative post marketing study included 100 patients with chemo-naïve advanced (stage iiib, iv) non-small cell lung cancer and eastern cooperative o...

Surgery remains the best curative option in patients with early stage lung cancer (stage I and II). Developments in minimally invasive techniques now allow surgeons to perform lung resections on elderly patients, patients with poor pulmonary function or significant cardiopulmonary comorbidities. New techniques, such as stereotactic radiotherapy and ablative procedures, are being evaluated in ea...

BACKGROUND Surgery for lung cancer invading the spine remains challenging associated with high morbidity and mortality. However, recent advances in surgical techniques as well as in perioperative care may improve outcomes of lung cancer surgery with vertebrectomy. We describe our surgical approach and assess the outcome lung cancer invading the spine. METHODS We retrospectively reviewed our r...

objective(s): chemoresistance remains the main causes of treatment failure and mortality in cancer patients. there is an urgent need to investigate novel approaches to improve current therapeutic modalities and increase cancer patients' survival. induction of drug efflux due to overexpression of                  p-glycoproteins is considered as an important leading cause of multidrug resis...

background: lung cancer is one of the fatal cancers in iran while 12% of the mortalities are related to this cancer in the country. this active hospital-based study was undertaken to determine the occurrence of lung cancer in fars province, southern iran. methods: data including face-to-face interview with patients and a survey of their medical and demographic records in relation to all invasiv...

cisplatin-based chemotherapy is the standard treatment for advanced non-small cell lung cancer (nsclc). many novel drugs have been used in combination with cisplatin in this setting. of these drugs, gemcitabine is reported to have a high response rate and acceptable toxicity. the aim of this study was to evaluate the efficacy and safety of gemcitabine and cisplatin combination. twentythree pati...

BACKGROUND Coexistent lung cancer and pulmonary tuberculosis is an urgent problem of thoracic surgery presenting a challenging task for diagnosis and surgical treatment. MATERIALS AND METHODS From 1990 to 2005, 2218 patients with lung cancer underwent surgical treatment in Department of Thoracic Surgery and Oncology, Institute of Oncology, Vilnius University. In 46 (2.1%) patients coexistence...

OBJECTIVES Lung cancer surgery leads to long term survival for some patients but little is known about how patients decide whether to accept the associated surgical risks. The objective of this qualitative study was to explore patients' attitudes to the risks associated with lung cancer surgery. METHODS Fifteen patients with resectable lung cancer, recruited via multi-disciplinary team meetin...

Accessible online at: www.karger.com/journals/res Lung cancer is a major public health problem of growing importance throughout the world with frustrating long-term survival of under 15%. A majority of patients are unresectable at time of diagnosis, and even in those deemed operable, comorbid problems often limit efforts at successful resection. Procedures designed to preserve pulmonary functio...

A central paradigm in the care of patients with lung cancer is to offer surgery with curative intent (and hopefully outcome) to as many patients as possible while performing as few unnecessary surgeries as possible. " Unnecessary " surgery must be defined first as surgery in patients with advanced stage disease, in whom (at this time) surgery offers no benefit over chemoradiation therapy. Exact...