Despite their practical and commercial relevance, there are few reports on the kinetics of growth and production of Chinese hamster ovary (CHO) cells-the most frequently used host for the industrial production of therapeutic proteins. We characterize the kinetics of cell growth, substrate consumption, and product formation in naive and monoclonal antibody (mAb) producing recombinant CHO cells. ...

the potential of bulk starter fermentation strategy for production of a cost-effective and safe source of β-galactosidase was investigated. three different bulk starter media with different compositions were selected, and an industrial yogurt starter culture strain, l. bulgaricus dsm 20081 was cultivated in these media under ph-controlled conditions (ph=5.6) at 43°c. the media consisted of 1) b...

The present study focuses on effects of initial pH on dibenzothiophene (DBT) desulfurization via 4S pathway by growing cells of Ralstonia eutropha. For so doing, temporal changes of biomass concentration, glucose as a sole carbon source, pH value, and 2-hydroxybiphenyl (2-HBP) formation have been monitored during the bioprocess. The biomass concentration has been modeled by the logistic equatio...

The present study focuses on effects of initial pH on dibenzothiophene (DBT) desulfurization via 4S pathway by growing cells of Ralstonia eutropha. For so doing, temporal changes of biomass concentration, glucose as a sole carbon source, pH value, and 2-hydroxybiphenyl (2-HBP) formation have been monitored during the bioprocess. The biomass concentration has been modeled by the logistic equatio...

level: advanced M athematically modeling the kinetics of batch and continuous cultivation allows you to not only calculate and evaluate the effects of process parameters, but also to forecast those parameters and duration of cultivation to develop a costeffective production process. Mathematical modeling microorganism cultivation was intensively developed in the second half of the last century....

Background: Schizophyllum commune, is one of the important medicinal-fungi foods in the world. Due to its important constituents such as extracellular and intracellular polysaccharides, it is widely used in industry and medicine. One of the important polysaccharides of this fungus is chitin-glucan complex (CGC). The aim of this study was to investigate the growth of native fungus Schizophyllum ...

Sulphated polysaccharides from brown seaweedss comprise a complex group of macromolecules with a wide range of important biological properties such as anticoagulant, antioxidant, antiproliferative, antitumoral, anticomplementary, anti-inflammatory, antiviral, antipeptic and antiadhesive activities. Fucoidan is one of the main sulphated fucan, mostly interesting for their biological activities s...