Ca(2+) mediates the functional coupling between L-type Ca(2+) channel (LTCC) and sarcoplasmic reticulum (SR) Ca(2+) release channel (ryanodine receptor, RyR), participating in key pathophysiological processes. This crosstalk manifests as the orthograde Ca(2+)-induced Ca(2+)-release (CICR) mechanism triggered by Ca(2+) influx, but also as the retrograde Ca(2+)-dependent inactivation (CDI) of LTC...

The aim of this study was to investigate the effects of nitric oxide (NO) and reactive oxygen species (ROS) on L-type calcium channel (LTCC) gating properties of cardiomyocytes during long-term isoproterenol (ISO) stimulation. Expression and activity of nNOS as well as S-nitrosylation of LTCC α1C subunit significantly decreased in the myocardium of SUS rats. Long-term ISO stimulation increased ...

Because microwave products in the consumer electronics market are continuous developing, device and component manufacturers have to seek new advanced integration, packaging and interconnection technologies, as size, cost and performance are critical factors for the success of a microwave product. One of the most promising integration technologies is the multilayer low temperature co-fired ceram...

Recent studies have shown that zinc ion (Zn) can behave as an intracellular signaling molecule. We previously demonstrated that mast cells stimulated through the high-affinity IgE receptor (FcεRI) rapidly release intracellular Zn from the endoplasmic reticulum (ER), and we named this phenomenon the "Zn wave". However, the molecules responsible for releasing Zn and the roles of the Zn wave were ...

A capacitively coupled contactless conductivity detector produced in Low Temperature Co-fired Ceramic (LTCC) technology for microchip capillary electrophoresis (CE) is reported in this work. Electrodes located outside the measurement channel are used to sense impedance variations caused by conductive ions. The application of LTCC in combination with contactless conductivity detection is very pr...

This paper reviews recent developments in integrated fluidic mesosystems, based on low-temperature co-fired ceramic (LTCC) technology, in this laboratory and elsewhere. LTCC is shown to be an advantageous technique for integrated fluidic systems, due to its simplicity, low cost and ease of integration with other technologies and components (silicon, polymer, circuit boards. Also, the techniques...

The onset of human parturition is associated with up-regulation of pro-inflammatory cytokines including tumor necrosis factor (TNF) as well as changes in ion flux, principally Ca(2+) and K(+), across the myometrial myocytes membrane. Elevation of intra-cellular Ca(2+) from the sarcoplasmic reticulum opens L-type Ca(2+) channels (LTCCs); in turn this increased calcium level activates MaxiK chann...

L-type calcium channel (LTCC) function is critical for electrical and cellular signaling in a diverse range of cell types. In cardiac muscle LTCC function (I Ca,L) provides trigger Ca 2+ for Ca2+-induced Ca release, and ICa,L kinetics is a critical determinant of action potential duration.1 LTCC blockade is an effective antihypertensive regimen, likely owing to contributions of ICa,L in vascula...

VTT Technical Research Centre of Finland Ltd. has developed and utilized Low Temperature Co-fired Ceramic (LTCC) technology for about 25 years. This paper presents our activities related to photonics millimetre-waves, including also a relevant literature survey. First short summary the is given. Especially, unique features LTCC are described in more details. In addition, several examples have b...

BACKGROUND Iron overload cardiomyopathy that prevails in some forms of hemosiderosis is caused by excessive deposition of iron into the heart tissue and ensuing damage caused by a raise in labile cell iron. The underlying mechanisms of iron uptake into cardiomyocytes in iron overload condition are still under investigation. Both L-type calcium channels (LTCC) and T-type calcium channels (TTCC) ...