Bardet-Biedl syndrome (BBS) is a highly pleiotropic autosomal recessive disorder associated with a wide range of phenotypes including obesity. However, the underlying mechanism remains unclear. Here, we show that neuronal BBSome is a critical determinant of energy balance through its role in the regulation of the trafficking of the long signaling form of the leptin receptor (LRb). Targeted disr...

Two hundred and seventeen total hip replacements were performed during a trial designed to assess the influence of a surgical isolator upon postoperative wound infection. The trial was controlled by performing 108 of the replacements in a standard plenumventilated theatre with twenty air changes/hr, which also housed the isolator procedures. Comparative postoperative wound infection rates were ...

This paper presents the development of a magnetorheological (MR) fluid-based variable stiffness and damping isolator for vibration suppressions. The MR fluid isolator used a sole MR control unit to achieve the variable stiffness and damping in stepless and relative large scope. A mathematical model of the isolator was derived, and a prototype of the MR fluid isolator was fabricated and its dyna...

In this paper, we focus on concurrent programs that use locks to achieve isolation of data accessed by critical sections of code. We present Isolator, an algorithm that guarantees isolation in well-behaved threads of a program that obey a locking discipline even in the presence of ill-behaved threads that disobey the locking discipline. Isolator uses code instrumentation, data replication, and ...

Lithol Rubine B (LRB; the disodium salt of 3-hydroxy-4-[(4-methyl-2-sulfophenyl) azo]-2-naphthalenecarboxylic acid) was detected using high-performance liquid chromatography with an electrochemical (antimony film on silver) detector (HPLC-ECD). For direct current (DC) mode, with the current at a constant potential, and measurements with suitable experimental parameters, a linear concentration f...

Integrated optical isolators will become necessary as optical networks continue to grow and the need for monolithic integration and greater functionality increases. This thesis presents a design for a polarization independent isolator which can be monolithically integrated with semiconductor lasers. Theory and measurements are used to select a material for the isolator. A polarization independe...

In order to upgrade the seismic resistibility of structures and enhance the functionality of an isolator, a new base isolator called the multiple trench friction pendulum system (MTFPS) is proposed in this study. The proposed MTFPS isolator is composed of a trench concave surface and several intermediate sliding plates in two orthogonal directions. Mathematical formulations have been derived to...

Vegetation plays a very important role of carbon (C) sinks in the global C cycle. With its complex terrain and diverse vegetation types, the Lancang River Basin (LRB) of southwest China has huge C storage capacity. Therefore, understanding the spatial variations and controlling mechanisms of vegetation C storage is important to understand the regional C cycle. In this study, data from a forest ...

Most G protein-coupled receptors (GPCRs) do not generate membrane currents in response to ligand-receptor binding (LRB). Here, we describe a novel technique using endocytosis as a bioassay that can detect activation of a GPCR in a way analogous to patch-clamp recording of an ion channel in a living cell. The confocal imaging technique, termed FM endocytosis imaging (FEI), can record ligand-GPCR...

The NTP lifetime rodent bioassay (LRB) is the "gold standard" for predicting human carcinogenicity. Unfortunately, little attempt has been made to validate it against human carcinogenicity. Here we show that the extremely limited data available do not support either of the two common interpretations of LRB results. If a risk-avoidance interpretation is used where any positive result in a sex/sp...