Epigallocatechin-3-gallate (EGCG) is a major bioactive compound in tea polyphenol extract. After ingestion, EGCG reaches the intestine and may commence anti-inflammation intestinal organ. Thus, this paper, anti-inflammatory effect of was studied using lipopolysaccharide (LPS)-induced inflammation RAW 264.7 cells. LPS induction instigated morphological deformation extensively which normalized by...

Acidic conditions combined with the presence of lipopolysaccharide (LPS) may increase permeability gastrointestinal epithelium. Feeding starch-rich starter to dairy calves is associated ruminal acidosis and decreases pH other segments tract, that affects tight junction regulator. The objective was evaluate effect combination different (7.4 vs. 6.0) LPS concentrations (0, 0.5, 10 ng/mL) in intes...

BACKGROUND Acne is an inflammatory skin disorder caused by inflammatory biomarkers. Magnesium ascorbyl phosphate (MAP) is a stable precursor of vitamin C. It achieves a constant delivery of vitamin C into the skin and has antioxidative effects. OBJECTIVE We performed this study to evaluate the effect of MAP on the expression of inflammatory biomarkers in cultured sebocytes. METHODS Reverse ...

BACKGROUND Periodontitis is prevalent in older humans. Limiting the inflammation associated with periodontitis may provide a therapy for this condition, because Gram-negative bacteria expressing lipopolysaccharide (LPS) have a key role in initiation of inflammation by activating macrophage functions. Because oxidized galectin-1 regulates macrophage functions in other systems, we sought to estab...

Methods Reconstituted human gingival epithelia (RHGE) were challenged with two isoforms of PgLPS together with E. coli LPS as the positive control. mRNA and proteins were harvested from tissues and culture supernatants were collected. Expression of pro-inflammatory and antiinflammatory cytokines was evaluated by Q-PCR and ELISA. Involvement of pattern recognition receptors and signaling pathway...

yersinia enterocolitica is rapidly emerging worldwide as an enteric pathogen and has become a major cause of diarrhea even in developed countries. the aim of this study was to characterize and genetic diversity analysis among y. enterocolitica strains isolated from fish and chicken sources.from 44 strains, 55% (24 strains) found to be positive for y. enterocolitica by colony morphology, biochem...

Abstract During sepsis, massive PAMPs and DAMPs are released initiate the TLR signaling to mediate immune response cell fate decision in cells. We have shown that Fibroblastic Reticular Cells (FRC)-based therapy improves outcome a mouse polymicrobial sepsis model. Modulating TLR4 TLR9 FRC regulates efficacy of FRC-based sepsis. However, whether thus affects is unknown. Here we aim understand ro...

BackgroundNeuroinflammation can occur during sepsis and is now regarded as the main mechanism underlying various related central nervous system (CNS) disorders. Another well-known factor causing neuroinflammation psychological stress. In current study, we examined effects of prior exposure to stress on sepsis-induced CNS symptoms.Experimental procedureBalb/c mice were subjected wet bedding for ...

Jaundice or hyperbilirubinaemia is a common complication of sepsis. UGT1A1 (UDP-glucuronosyltransferase 1A1) is a critical gene for bilirubin metabolism and irinotecan detoxification. However, the molecular pathogenesis of hyperbilirubinaemia during inflammation needs to be further clarified. Human hepatic UGT1A1 expression was analysed by RT (reverse transcription)-PCR, qRT-PCR (quantitative r...