نتایج جستجو برای: lox tank

تعداد نتایج: 17601  

1985
Ethan A. Scarl John R. Jamieson Carl I. Delaune

Process-monitor ing and f a u l t loca t ion techniques have been developed at the Kennedy Space Center in a domain of mixed media con t ro l in NASA's Space Shut t le Launch Processing System. An i n t u i t i v e l y appealing d iagnost ic technique and representat ion of the system's s t ruc tu re and func t ion were formulated in cooperation w i th system engineers. Funct ional re la t ions...

2016
Raveendra Aanangi Kasi Viswanath Kotapati Bhagath Kumar Palaka Thyagaraju Kedam Nirmala Devi Kanika Dinakara Rao Ampasala

This study reports purification and characterization of lipoxygenase protein from mung bean germinating seedlings. Lipoxygenases (LOXs) are key enzymes in seed germination. The purified mung bean LOX has resolved into two peaks by chromatofocusing, one has highest LOX activity with an isoelectric point of 5.84 and the other has lowest LOX activity with an isoelectric point of 5.52. The purified...

Journal: :Cancer research 1998
D Nie G G Hillman T Geddes K Tang C Pierson D J Grignon K V Honn

Previously, we found a positive correlation between the expression of platelet-type 12-lipoxygenase (12-LOX) and the progression of human prostate adenocarcinoma (PCa; Gao et al., Urology, 46: 227-237, 1995). To determine the role of 12-LOX in PCa progression, we generated stable 12-LOX-transfected PC3 cells, which synthesize high levels of 12-LOX protein and 12(S)-hydroxyeicosatetraenoic acid ...

2013
Noelia Agra Florencia Cidre Laura García-García Juan de la Parra Javier Alonso

Ewing sarcoma is the second most common bone malignancy in children and young adults. It is driven by oncogenic fusion proteins (i.e. EWS/FLI1) acting as aberrant transcription factors that upregulate and downregulate target genes, leading to cellular transformation. Thus, identificating these target genes and understanding their contribution to Ewing sarcoma tumorigenesis are key for the devel...

2007
Min Wu Chengyin Min Xiaobo Wang Ziyang Yu Kathrin H. Kirsch Philip C. Trackman Gail E. Sonenshein

The gene encoding lysyl oxidase (LOX) was identified as the ras recision gene (rrg), with the ability to revert Ras-mediated transformation of NIH 3T3 fibroblasts. Mutations in RAS genes have been found in f25% of lung cancers and in 85% of pancreatic cancers. In microarray analysis, these cancers were found to display reduced LOX gene expression. Thus, the ability of the LOX gene to repress th...

2013
FANG JI YOU WANG LIHUA QIU SHU LI JING ZHU ZHOU LIANG YINSHENG WAN WEN DI

This study investigated the role of LOX in promoting invasion and metastasis of epithelial ovarian cancer in a hypoxic environment and its specific signal transduction pathway. Immunohistochemical detection of HIF-1α and LOX protein expression was performed on formalin-fixed paraffin sections of normal ovary, benign ovarian tumors, borderline and malignant epithelial ovarian tumor paraffin samp...

Journal: :The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2008
Milos D Ikonomovic Eric E Abrahamson Tolga Uz Hari Manev Steven T Dekosky

The proinflammatory enzyme 5-lipoxygenase (5-LOX) is upregulated in Alzheimer's disease (AD), but its localization and association with the hallmark lesions of the disease, beta-amyloid (Abeta) plaques and neurofibrillary tangles (NFTs), is unknown. This study examined the distribution and cellular localization of 5-LOX in the medial temporal lobe from AD and control subjects. The spatial relat...

Journal: :The Journal of biological chemistry 2007
Noemi Polgar Ben Fogelgren J Michael Shipley Katalin Csiszar

Lysyl oxidase (LOX), an extracellular amine oxidase, catalyzes the cross-linking of collagen and elastin. LOX has been also shown to play an essential role in promoting the invasive and metastatic potential of breast tumor cells. However, the LOX-interacting factors in these processes are not known. In this study, we identified placental lactogen (PL), a member of the growth hormone/prolactin h...

Journal: :International journal of clinical and experimental pathology 2014
Juan Liu Wei Ping Yukun Zu Wei Sun

Lysyl oxidase (LOX) has been reported to regulate tumor metastasis and has been found to involve in modification of extracellular matrix (ECM) in the context of tumorigenesis. The aim of this study is to determine the prognostic significance of LOX in non-small cell lung cancer (NSCLC) patients and to examine the correlation between LOX expression and ECM remodeling-associated MMP2/MMP9 in NSCL...

2014
Tomofumi Misaka Satoshi Suzuki Nobuo Sakamoto Takayoshi Yamaki Koichi Sugimoto Hiroyuki Kunii Kazuhiko Nakazato Shu-ichi Saitoh Tatsuya Sawamura Toshiyuki Ishibashi Yasuchika Takeishi

BACKGROUND Soluble lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) level is a novel biomarker for diagnosis of acute coronary syndrome (ACS); however, this level in the coronary circulation has yet to be examined. METHODS Twenty-seven consecutive patients with ACS and 40 patients with effort angina pectoris (EAP) undergoing percutaneous coronary intervention (PCI) had levels o...

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