نتایج جستجو برای: lox 1 receptor

تعداد نتایج: 3118924  

Journal: :Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2016
Dimitry A Chistiakov Alexander N Orekhov Yuri V Bobryshev

In healthy arteries, expression of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is almost undetectable. However, in proatherogenic conditions, LOX-1 is markedly up-regulated in vascular cells. In atherosclerosis, LOX-1 appears to be the key scavenger receptor for binding oxidized LDL (oxLDL). Notably, a positive feedback exists between LOX-1 and oxLDL. LOX-1 is involved in me...

Journal: :Circulation 2000
D Li J L Mehta

BACKGROUND We have recently demonstrated a lectin-like receptor for oxidized (ox)-LDL (LOX-1) in human coronary artery endothelial cells (HCAECs). This receptor is upregulated by ox-LDL. The present study examined the significance of LOX-1 in monocyte adhesion to HCAECs and endothelial injury in response to ox-LDL. METHODS AND RESULTS HCAECs were incubated in the presence of antisense oligode...

Journal: :Biochemical and biophysical research communications 2001
H Morawietz N Duerrschmidt B Niemann J Galle T Sawamura J Holtz

In this study, we analyzed the effect of endothelin-1 (ET-1) on expression of the lectin-like oxidized low-density lipoprotein (oxLDL) receptor-1 LOX-1 and on oxLDL uptake in primary cultures of human umbilical vein endothelial cells (HUVEC). LOX-1 mRNA was quantified by standard-calibrated competitive RT-PCR, LOX-1 protein expression by Western analysis and endothelial oxLDL uptake using DiI-l...

2013
Angela Pirillo Giuseppe Danilo Norata Alberico Luigi Catapano

Oxidized low-density lipoprotein (OxLDL) contributes to the atherosclerotic plaque formation and progression by several mechanisms, including the induction of endothelial cell activation and dysfunction, macrophage foam cell formation, and smooth muscle cell migration and proliferation. Vascular wall cells express on their surface several scavenger receptors that mediate the cellular effects of...

2015
SangKon Oh HyeMee Joo

Lectin-like oxidized low-density lipoprotein (LDL) receptor-1 (LOX-1) is a class E scavenger receptor that is encoded by the OLR1 gene on human chromosome 12. LOX-1 is expressed as a type II transmembrane protein containing four domains: an extracellular C-terminal lectin domain, a connecting neck domain, a single transcellular domain and a short N-terminal cytoplasmic tail. A disulfide bond be...

Journal: :Journal of cell science 2011
Ku-Chung Chen I-Chung Hsieh Edward Hsi Yung-Song Wang Chia-Yen Dai Wen-Wen Chou Suh-Hang Hank Juo

Lectin-like oxidized LDL receptor-1 (LOX-1) is a surface scavenger receptor for oxidized low-density lipoprotein (oxLDL). Several transcription factors have been reported to regulate LOX-1 expression. MicroRNAs are small noncoding RNAs that control gene expression, but there have been no reports of LOX-1 expression being regulated by microRNAs. Because the microRNA let-7g has been predicted to ...

Journal: :Circulation 2001
E Iwai-Kanai K Hasegawa T Sawamura M Fujita T Yanazume S Toyokuni S Adachi Y Kihara S Sasayama

BACKGROUND Lectin-like oxidized LDL receptor-1 (LOX-1) was originally identified as a receptor expressed predominantly in endothelial cells. LOX-1 can also be expressed in other cell types, and the activation of the LOX-1 pathway has been implicated in apoptosis. There have been no reports, however, about LOX-1 expression in cardiac myocytes or regulation of myocardial cell apoptosis by LOX-1. ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2003
Megumi Honjo Kayo Nakamura Kenji Yamashiro Junichi Kiryu Hidenobu Tanihara Leslie M McEvoy Yoshihito Honda Eugene C Butcher Tomoh Masaki Tatsuya Sawamura

Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a major endothelial receptor for oxidized low-density lipoprotein, and is assumed to play a proatherogenic role in atherosclerosis. LOX-1 expression is induced by inflammatory cytokines as well as by proatherogenic stimuli. LOX-1 protein binds agedapoptotic cells, activated platelets, and bacteria, suggesting that it may have di...

2017
Floor Spaans Cindy K Kao Jude S Morton Anita L Quon Tatsuya Sawamura Dionne S Tannetta Ian L Sargent Sandra T Davidge

Syncytiotrophoblast extracellular vesicles (STBEVs) are placenta derived particles that are released into the maternal circulation during pregnancy. Abnormal levels of STBEVs have been proposed to affect maternal vascular function. The lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a multi-ligand scavenger receptor. Increased LOX-1 expression and activation has been proposed...

Journal: :Cardiovascular research 2006
Jun-ichi Hinagata Makoto Kakutani Takao Fujii Takahiko Naruko Nobutaka Inoue Yoshiko Fujita Jawahar L Mehta Makiko Ueda Tatsuya Sawamura

OBJECTIVE LOX-1 is a multi-ligand receptor originally identified as the endothelial oxidized LDL receptor. LOX-1 expression is also induced in smooth muscle cells in response to proinflammatory and oxidative stimuli. Here, we report on the role of LOX-1 in intimal hyperplasia, in which proinflammatory and oxidative stimuli are increased. METHODS AND RESULTS Left common carotid artery of rat w...

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