نتایج جستجو برای: lowdensity lipoprotein ldl
تعداد نتایج: 66227 فیلتر نتایج به سال:
background: oxidative modification of low-density lipoprotein (ldl) appears to be an early step in the pathogenesis of atherosclerosis. meanwhile, myeloperoxidase (mpo)-catalyzed reaction is one of the potent pathway for ldl oxidation in vivo. the aim of this study was to evaluate in vitro antioxidant effects of vitamins c and e on ldl oxidation mediated by mpo. methods: mpo was isolated from f...
1933-2874/$ see front matter 2014 http://dx.doi.org/10.1016/j.jacl.2014.03 Statins are the most widely prescribed class of medications in the United States and their benefits for lowering lowdensity lipoprotein cholesterol (LDL-C) and reducing the risk for coronary heart disease (CHD) are well documented. Statins have been the cornerstone of pharmacotherapy for the management of high blood chol...
Dyslipidemia is one of the major modifiable risk factors for coronary heart disease (CHD), the leading killer of men and women in the United States [1]. Most patients with CHD have multiple lipid abnormalities, and a management approach focusing exclusively on lowdensity lipoprotein cholesterol (LDL-C) reduction fails to address the added atherogenic potential that has been shown to exist when ...
At serum cholesterol levels higher than 5 m ~ the risk for coronary heart disease mortality increases progressively with serum cholesterol concentration (Martin el al., 1986). There is good evidence now that reduction of serum cholesterol in hypercholesterolaemic men can reduce the incidence of coronary heart disease (Lipid Research Clinics Program, 1984). More insight into the regulation of ch...
background: a great deal of evidence has indicated that oxidatively modified ldl plays a critical role in the initiation and progression of atherosclerosis. antioxidants that can prevent ldl oxidation may act as antiatherogens. copper is a candidate for oxidizing ldl in atherosclerotic lesions. the binding of copper ions to ldl is usually thought to be a prerequisite for ldl oxidation by copper...
Low-density lipoprotein (LDL) indubitably contributes causally to atherosclerosis, a leading challenge health worldwide. Interventions that lower LDL cholesterol (LDL-C) have made remarkable inroads against this global scourge. Recent therapeutic advances achieved ever levels of LDL-C. Improved cardiovascular outcomes continue accrue from these interventions. In particular, the discovery role p...
Binding of urokinase-type plasminogen activator–plasminogen activator inhibitor-1 complex to the endocytosis receptors α2-macroglobulin receptor/low-density lipoprotein receptor-related protein and very-lowdensity lipoprotein receptor involves basic residues in the inhibitor Kees W. RODENBURG, Lars KJØLLER, Helle H. PETERSEN and Peter A. ANDREASEN Department of Molecular and Structural Biology,...
References 1. Steinberg D. Low density lipoprotein oxidation and its pathobiological significance. J Biol Chem 1997;272:20963–6. 2. Holvoet P, Collen D. Oxidation of low density lipoproteins in the pathogenesis of atherosclerosis. Atherosclerosis 1998;137(Suppl):S33–8. 3. Diaz MN, Frei B, Vita JA, Keaney JF Jr. Antioxidants and atherosclerotic heart disease. N Engl J Med 1997;337:408–16. 4. Dau...
Oxidation of low density lipoprotein (LDL) by cells of the arterial wall or in the presence of copper ions was shown to result in the peroxidation of its fatty acids as well as its cholesterol moiety. LDL incubation with cholesterol oxidase (CO) resulted in the conversion of up to 85% of the lipoprotein unesterified cholesterol (cholest-5-en-3-ol) to cholestenone (cholest-4-en-3-one) in a dose-...
previous studies have shown that diabetes mellitus (dm) increases the risk of cardiovascular disease in women to a greater extent than in men. it seems that dm may alter lipid profiles more adversely in women compared to men. in this study we evaluated serum lipoprotein differences in type 2 diabetic men and women. the study included 350 type 2 diabetic patients (100 men and 250 women), aged 19...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید