*Correspondence: T. D. Silva. Departamento de Farmácia. Faculdade de Ciências Biológicas e da Saúde. Universidade Federal dos Vales do Jequitinhonha e Mucuri, Campus JK. Rodovia MGT 367, Km 583, n° 5000, 39100-000, Diamantina, MG, Brasil. E-mail: [email protected] Development and validation of alternative methods by non-aqueous acid-base titration and derivative ultraviolet spectrophoto...

A first-derivative spectrophotometric method was developed for quantitative determination of two synthetic organic dyes, Carmoisine and Patent Blue V, which are under governmental regulations all over the world because of their toxicity and carcinogenity. In this study, Carmoisine and Patent Blue V were simultaneously determined in their binary mixtures by first-derivative spectrophotometry. Th...

Two methods for the simultaneous estimation of atenolol and hydrochlorothiazide in combined tablet dosage form have been developed. The first method is the Q-analysis method, based on absorbance ratio at two selected wave lengths 232.0nm (Iso-absorptive point) and 270.0nm (λmax of hydrochlorothiazide). The second method is the first order derivative spectroscopy using 214.0nm (zero cross for at...

The study was conducted to evaluate the anti-atherogenic potential of losartan and to assess the effects of hydrochlorothiazide and indapamide on losartan activity in rat. Cholesterol diet (0.5%) for 12 weeks led to significant hyperlipidemia, increased body weight and oxidative stress in erythrocyte. While, losartan, hydrochlorothiazide and indapamide treatment continued for next 12 weeks, los...

iron is quantitatively retained on an adsorbent made by coprecipitation of 1,2-dihydroxybenzene-3,5-disulfonic acid (tiron) and tetradecyldimethylbenzylammonium choride (tdba) an microcrystalline naphthalene as a slurry or packed in a column, in the ph range 6.0-9.0 from a large volumes of aqueous solutions (up to 200 ml on microcrystalline naphthalene and up to 500 ml of aqueous solutions in t...

tropicamide is an antimuscarinic agent used as eye drops for refractive examinations. the aim of this study was to develop a simple and suitable analytical method for determination of tropicamide in eye drops in the presence of excipients. a zero-crossing third and fourth derivative spectrophotometric method was described for determination of tropicamide in eye drops. the measurements were carr...

BACKGROUND Paraquat (PQ) is a world-wide used herbicide and also a type of common poison for suicide and accidental poisoning. Numerous studies have proved that the concentration of serum PQ plays an important role in prognosis. Spectrophotometry, including common spectrophotometry and second-derivative spectrophotometry, is commonly used for PQ detection in primary hospitals. So far, lack of s...

A fixed-dose combination of losartan/hydrochlorothiazide (HCTZ) therapy may be a logical choice for antihypertensive treatment, including for initial therapy in patients with blood pressure elevation >20/10 mmHg above treatment target. The renin-angiotensin-aldosterone-system-activating effect of hydrochlorothiazide augments the efficacy of blocking the angiotensin II type 1 (AT1) receptor with...

Various aspects of application of derivative spectrophotometry in chemical analysis and in investigations of equilibria and kinetics of reactions are scrutinized. The presented paper provides useful information about state-of-the-art and possibilities offered by derivative spectrophotometry in pharmaceutical, clinical or environmental fields of analysis.