BACKGROUND The aim of the study was to evaluate the effect of lornoxicam (L) on sensory and motor block onset time, tourniquet pain, and postoperative analgesia, when added to lidocaine in intravenous regional anaesthesia (IVRA). METHODS Forty-five patients undergoing hand surgery were randomly and blindly divided into three groups as to receive either i.v. saline and IVRA with lidocaine 0.5%...

BACKGROUND In this experiment, the effects of lornoxicam on brain edema and the blood brain barrier (BBB) following diffuse traumatic brain injury (TBI) were studied. METHODS Twenty adult male Wistar albino rats were anesthetized, and experimental closed head trauma was induced by the Marmarou method. After head injury, the rats were randomly divided into two groups: Group I was the control g...

BACKGROUND This study was conducted to compare and evaluate the effect of adding lornoxicam or nitroglycerine as adjuncts to lidocaine in intravenous regional anesthesia (IVRA). METHODS 60 patients were randomly separated into three groups, lidocaine group (group L), lidocaine+lornoxicam group (group LL), and lidocaine+lornoxicam+transdermal nitroglycerine group (group LL-N). Hemodynamic para...

OBJECTIVE In this study, we aimed comparing early postoperative period analgesic effectiveness and the effects on opioid consumption of intravenous dexketoprofen and lornoxicam that are given preemptively. MATERIALS AND METHODS Forty patients, planned elective mediastinoscopy, were included in this prospective randomized study. These patients were classified in two groups, group D for dexketo...

The purpose of this study was to design novel drug delivery system containing Lornoxicam microsponges. Lornoxicam is a Non-steroidal anti-inflammatory drug used for the treatment of various inflammatory diseases. Microsponges containing Lornoxicam and Eudragit RS 100 were prepared by quasi emulsion solvent diffusion method. The effects of drug to polymer ratios on physical characteristics of th...

PURPOSE We compared the effects of local levobupivacaine infiltration, intravenous paracetamol, intravenous lornoxicam treatments on postoperative analgesia in patients submitted to transperitoneal laparoscopic renal and adrenal surgery. MATERIALS AND METHODS Sixty adult patients 26 and 70 years who underwent laparoscopic renal and adrenal surgery were randomized into three groups with 20 pat...

The aim of the present study is to formulate and evaluate the Immediate release oral dispersible film formulation of lornoxicam with different ratios polymeric combinations by the solvent evaporation technique. . Lornoxicam, a potent non-steroidal antiinflammatory drug (NSAID) with shorter half life, makes the development of immediate release dosage forms extremely advantageous. These formulati...

objective(s): the aim of present research was to develop matrix-mini-tablets of lornoxicam filled in capsule for targeting early morning peak symptoms of rheumatoid arthritis. materials and methods:matrix-mini-tablets of lornoxicam were prepared by direct compression method using microsomal enzyme dependent and ph-sensitive polymers which were further filled into an empty hpmc capsule. to asses...

OBJECTIVES The present study sought to compare the analgesic efficacy and adverse effects of intravenous (IV) lornoxicam and tramadol to investigate if lornoxicam is a reasonable alternative to a weak opioid for post-thyroidectomy pain. METHODS Fifty patients of American Society of Anesthesiologists class I or II, 18 to 65 years of age, and who underwent thyroidectomy were assigned to 2 group...