Introduction: Congenital long QT syndrome (LQTS) is a cardiac disorder characterized by QT interval prolongation at basal ECG. Different LQTS genes encode ion channel subunits or proteins involved in regulating cardiac ionic currents. Long QT syndrome type 6 (LQT6) is caused by mutation in the KCNE2 gene. Our research aimed to analyze genetic variants of KCNE2 gene causing the disease in Irania...

how to cite this article: movahedian ah, heidarzadeh arani m, motaharizad m, mousavi gha, mosayebi z. evaluation of qt dispersion in children with breath holding spells. iran j child neurol. winter 2016; 10(1):25-30. abstract objective breath holding spells (bhs) are common involuntary reflexes in infancy and early childhood. differential diagnosis should embrace long qt syndrome (lqts) and par...

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It is generally assumed that long QT syndrome (LQTS) is an arrhythmic disorder that occurs in patients with normal left ventricular systolic function. The present article by Haugaa et al challenges this assumption.1 One hundred and one patients with genetically documented LQTS were systematically compared to an age-matched unaffected control population for differences in regional contraction pa...

Long QT syndrome is characterized by prolongation of the corrected QT (QTc) interval on the surface electrocardiogram and is associated with precipitation of torsade de pointes (TdP), a polymorphic ventricular tachycardia that may cause sudden death. Acquired long QT syndrome describes pathologic excessive prolongation of the QT interval, upon exposure to an environmental stressor, with reversi...

BACKGROUND Congenital long-QT syndrome is a disorder resulting in ventricular arrhythmias and sudden death. The most common forms of the long-QT syndrome, types 1 and 2, are caused by mutations in the potassium-channel genes KCNQ1 and KCNH2, respectively. Although inheritance of the long-QT syndrome is autosomal dominant, female predominance has often been observed and has been attributed to an...