Methods All HIV1-positive patients of the participating clinic wards, aged over 13 and giving informed consent are included in the cohort. Patients receiving a first prescription of NVP between 1997 and 2008 are described at baseline and during follow-up according to their treatment status, ART-naïve or not. Chi-square test, signed rank Wilcoxon test, Mc Nemar test and log-rank test are used fo...

Inhibitor of differentiation/DNA binding (Id) proteins are transcription factors, involved in cell cycle regulation and neoangiogenesis. Using immunohistochemistry, we investigated the prognostic influence of Id-1, Id-2, and Id-3 expression in 89 patients with cervical cancer stage pT(1b). In univariate and multivariate analysis, patients with strong or moderate expression of Id-1 had a signifi...

Hypoxia-inducible factor 1alpha (HIF-1alpha) is a transcriptional factor that regulates genes involved in response to hypoxia and promotes neoangiogenesis, which are considered essential for tumor growth and progression. Using immunohistochemistry, we investigated the influence of HIF-1alpha expression on prognosis in 91 patients with cervical cancer stage pT1b. In univariate and multivariate a...

BACKGROUND AIB1 (SRC-3) is an estrogen receptor (ER) coactivator that, when overexpressed in cultured cells, can reduce the antagonist activity of tamoxifen-bound ERs. Signaling through the HER-2 receptor pathway activates AIB1 by phosphorylation. To determine whether high AIB1 expression alone or together with HER-2 reduces the effectiveness of tamoxifen in breast cancer patients, we quantifie...

Deriving clinical utility from large genomic datasets requires the identification of statistically significant associations between genomic measurements and a clinical phenotype. An important instance of this problem is to identify genetic variants that distinguish patients with different survival time following diagnosis or treatment. The most widely used statistical test for comparing the sur...

Model Suppose a set G of genes was sequenced in a collection P of patients, all of whom have the same disease. Each sequenced gene2 g ∈ G partitions the set of patients into two subsets: the P(g), with patients with a mutation in g, and the P̄(g), with patients with no mutation in g. The goal is to identify genes whose mutational status is highly correlated with the survival time, in the sense t...