Finding a treatment for spinal cord injury (SCI) focuses on reconnecting the spinal cord by promoting regeneration across the lesion site. However, while regeneration is necessary for recovery, on its own it may not be sufficient. This presumably reflects the requirement for regenerated inputs to interact appropriately with the spinal cord, making sub-lesion network properties an additional inf...

BACKGROUND/AIMS Schwann cells (SCs) which were demonstrated to be responsible for axonal myelination and ensheathing are widely studied and commonly used for cell transplantation to treat spinal cord injury (SCI). We performed this meta-analysis to summarize the effects of SCs versus controls for locomotor recovery in rat models of traumatic SCI. METHODS Studies of the BBB scores after transp...

GAIN AND LOSS OF FUNCTIONAL LOCOMOTOR RECOVERY FOLLOWING CONTUSIVE SPINAL CORD INJURY IN THE ADULT RAT Krista Layne Caudle November 14,2012 Activity-based rehabilitation in the form of overground or body weightsupported treadmill (BWST) locomotor step training has become the most widely accepted therapy translated from preclinical animal research to spinal cord injury (SCI) patients. However, l...

Accurate diagnosis of spinal cord injury (SCI) severity must be achieved before highly aggressive experimental therapies can be tested responsibly in the early phases after trauma. These studies demonstrate for the first time that axial diffusivity (lambda||), derived from diffusion tensor imaging (DTI) within 3 h after SCI, accurately predicts long-term locomotor behavioral recovery in mice. F...

in the present study, the effect of apamin (potassium channel blocker) on tolerance to cocaine-induced locomotor activity in mice has been investigated. locomotor activity was measured by locomotor activity meter, animax, type s (lkb, farrad). intraperitoneal (ip) injection of different doses of cocaine (2.5, 5, 10 and 15 mg/kg) produced dose-dependent locomotor activity in mice.animals were tr...

Knowledge of which tracts are essential for the recovery of locomotor function in rats after repair is unknown. To assess the mechanism of recovery, we examined the correlation between functional recovery and axonal regeneration. All rats underwent complete cord transection and repair with peripheral nerves, fibroblast growth factor 1, fibrin glue, and spinal fixation. Repaired rats recovered b...

Introduction: Spinal cord injuries are accompanied with significant demyelination of axons and subsequent locomotor dysfunction. To identify the extent of damage following electrolytic lesion of ventrolateral white matter, essential area for initiation of locomotor activity, we assessed demyelination as well as alteration in motor performance. Moreover, the protective effect of estradiol as a c...

objective: several studies have shown that, although transplantation of neural stem cells into the contusion model of spinal cord injury (sci) promotes locomotor function and improves functional recovery, it induces a painful response, allodynia. different studies indicate that bone marrow stromal cells (bmscs) and schwann cells (scs) can improve locomotor recovery when transplanted into the in...

This review discusses some aspects of plasticity of connections after spinal injury in adult animal models as a basis for functional recovery of locomotion. After reviewing some pitfalls that must be avoided when claiming functional recovery and the importance of a conceptual framework for the control of locomotion, locomotor recovery after spinal lesions, mainly in cats, is summarized. It is c...