BACKGROUND Ageing is associated with a decline of motor function and ability to perform daily activities. Locomotive disorders are one of the major disorders resulting in adverse health condition in elderly people. Concept of Locomotive syndrome (LoS) was proposed to tackle the problems and prolong healthy life expectancy of people with locomotive disorders. To develop intervention strategy for...

Progress made in predicting illness will alter information on the risk of illness. Whereas formerly we all shared the same uncertainty insofar as our health was concerned and believed ourselves to be equal in the face of illness, we now know that we do not all have the same chances. The genetic revolution at the root of this upheaval will, of course, have important consequences for private insu...

Locomotives are complex electromechanical systems. Continuously monitoring the health state of locomotives is critical in modern cost-effective maintenance strategy. A typical locomotive is equipped with the capability to monitor their state and generate fault messages and a snapshot of sensed parametric readings in response to anomalous conditions. In our previous studies, we have developed an...

For most mammals, running is their major locomotive style, however, cetaceans and bats are two mammalian groups that have independently developed new locomotive styles (swimming and flying) from their terrestrial ancestors. In this study, we used a genome-wide comparative analysis in an attempt to identify the selective imprint of the development of new locomotive styles by cetaceans and bats t...

When plasmodia of the true slime mold Physarum were exposed to unfavorable conditions presented as three consecutive pulses at constant intervals, they reduced their locomotive speed in response to each episode. When the plasmodia were subsequently subjected to favorable conditions, they spontaneously reduced their locomotive speed at the time when the next unfavorable episode would have occurr...

We develop a new hidden Markov model-based method to analyze C elegans locomotive behavior and use this method to quantitatively characterize behavioral states. In agreement with previous work, we find states corresponding to roaming, dwelling, and quiescence. However, we also find evidence for a continuum of intermediate states. We suggest that roaming, dwelling, and quiescence may best be tho...

Abstract. In this paper, we give an overview of the Locomotive Simulater/Optimizer (LSO) decision support system developed by us for railroads. This software is designed to imitate locomotive movement across a rail network, and it simulates all four major components of the system; trains, locomotives, terminals, and shops in an integrated framework. It includes about 20 charts that allow evalua...