نتایج جستجو برای: locked nucleic acid
تعداد نتایج: 773157 فیلتر نتایج به سال:
Triplex forming oligonucleotides (TFOs) modified with C5-alkynyl functionalized LNA (locked nucleic acid) monomers display extraordinary thermal affinity toward double stranded DNA targets, excellent discrimination of Hoogsteen-mismatched targets, and high stability against 3?-exonucleases.
Polymerase chain reaction amplification of a locked nucleic acid (LNA)-modified DNA strand and transcription reactions using LNA-A nucleoside 5'-triphosphate were successfully accomplished with DNA and RNA polymerases.
trichophyton rubrum (t. rubrum) is an anthropophilic dermatophyte that is distributed worldwide and causes common cutaneous disease such as mycosis. although several properties of this fungus have been investigated so far, however a few studies were carried out in the field of molecular biology of this fungus. in the present study we tried to identify its molecular characterization of the goano...
Increased awareness of the importance of microRNAs goes hand in hand with an increased need to follow their expression. Their small size of 22 nucleotides makes tracking them a challenge that requires new approaches and technology. Neely and colleagues now developed a method for detection of microRNA expression using locked nucleic acid probes and a multicolor confocal laser system; they achiev...
a label-free electrochemical nucleic acid aptasensor for the detection of methamphetamine (ma) by the immobilization of thiolated self-assembled dna sequences on a gold nanoparticles-chitosan modified electrode is constructed. when ma was complexed specifically to the aptamer, the configuration of the nucleic acid aptamer switched to a locked structure and the interface of the biosensor changed...
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