BACKGROUND AND AIMS Patients on home parenteral nutrition (HPN) are at risk for catheter-related complications; mainly infections and occlusions. We have previously shown in HPN patients presenting with catheter sepsis that catheter locking with taurolidine dramatically reduced re-infections when compared with heparin. Our HPN population therefore switched from heparin to taurolidine in 2008. T...

OBJECTIVES The use of an antibiotic lock (AB-lock) for the treatment of catheter-related bloodstream infection (CRBSI) has been suggested, but randomized trials have never been performed. METHODS A randomized, blinded, multicentre trial was set up to compare an AB-lock-containing vancomycin for Gram-positive or ceftazidime for Gram-negative bacteria-with placebo, in addition to parenteral AB ...

BACKGROUND Central-line-associated blood-stream infection (CLABSI) is a highly consequential nosocomial infection. The most effective management includes the removal of the infected catheter. Retention of the catheter and antibiotic lock therapy (ALT) along with systemic antibiotics may be attempted only if there are unusual extenuating circumstances. CLABSIs due to Gram-negative bacteria (GNB)...

OBJECTIVE To investigate the effect of antibiotic lock solutions for preventing catheter-related bacteraemia in patients receiving haemodialysis. DESIGN Retrospective study. SETTING University teaching hospital, Hong Kong. PATIENTS Consecutive patients from March 2006 to April 2007 who had central venous catheter insertion for haemodialysis in our centre were included in this historically...

1. MCINTYRE CW, HULME LJ, TAAL M, FLUCK RJ: Locking of tunneled hemodialysis catheters with gentamicin and heparin. Kidney Int 66:801–805, 2004 2. DOGRA GK, HERSON H, HUTCHISON B, et al: Prevention of tunnelled haemodialysis catheter-related infections using catheter-restricted filling of gentamicin and citrate: A randomised control study. J Am Soc Nephrol 13:2133–2139, 2002 3. SAXENA AK, PANHO...

Abstract Background and Aims The incidence of peritonitis has markedly decreased in the last decades, nevertheless it remains one main causes catheter removal subsequent dialysis modality change. In long-term severe relapses can lead to peritoneal membrane failure. Some bacteria form biofilms lumen granting them resistance against antibiotics thus being for infection recurrences. To find a viab...

Antibiotic-lock is a treatment for catheter-related bloodstream infections in which a solution containing heparin and an antibiotic dwells in the lumen of the catheter or port. We tested the stability of vancomycin, cefazolin, ticarcillin-clavulanic acid, ceftazidime, or ciprofloxacin combined with heparin after incubation in vitro at 25 or 37 degrees C for intervals of up to 10 days by bioassa...

Central venous catheter-related blood stream infection is a major cause of morbidity and mortality in patients with renal disease treated with hemodialysis. Antibiotic lock solutions can be effective in preventing this complication in patients with hemodialysis. Searching in Epistemonikos database, which is maintained by screening more than twenty databases, we identified eight systematic revie...

OBJECTIVES To use the ethanol-lock technique (in conjunction with systemic antibiotics) to salvage central lines from removal and to prevent persistence of catheter-related infections among pediatric patients with long-term intravascular devices. DESIGN Medical records of patients treated with ethanol locks were retrospectively reviewed from June 1, 2004, through June 22, 2005. SETTING Chil...