Whether preemptive analgesic interventions are more effective than conventional regimens in managing acute postoperative pain remains controversial. We systematically searched for randomized controlled trials that specifically compared preoperative analgesic interventions with similar postoperative analgesic interventions via the same route. The retrieved reports were stratified according to fi...

Background: Local infiltration analgesia pumps have been increasingly used to provide postoperative pain relief. However, their flow rate over time may not be reliable and accurate which can pose concerns regarding the achievement of the desired therapeutic level. We sought to find out in vitro if the flow rate of two elastomeric infusion pumps when combined with two types of wound catheter is ...

The tumescent technique for local anesthesia permits regional local anesthesia of the skin and subcutaneous tissues by direct infiltration. The tumescent technique uses large volumes of a dilute anesthetic solution to produce swelling and firmness of targeted areas. This investigation examines the absorption pharmacokinetics of dilute solutions of lidocaine (0.1% or 0.05%) and epinephrine (1:1,...

BACKGROUND Subcutaneous or intrafascial wound infiltration of local anaesthetic with systemic opioids has been shown to enhance patient comfort with improved analgesia and reduced opioid requirements. OBJECTIVE To demonstrate improved pulmonary function when postoperative analgesia was provided by combined bupivacaine wound infiltration and systemic opioid. METHODS In a prospective, randomi...