We report herein five new coordination polymers of general formula [LnNa(C(6)H(5)CO(2))(4)] where Ln = Y (6), Tb (7), Er (8), [DyNa(CH(3)CO(2))(4)(MeOH)] (9) and [DyNa(C(3)H(7)CO(2))(4)] (10). Single crystal structure analyses revealed that all compounds have a repeating unit containing one Ln(3+), one Na(+) and four monocarboxylate ligands (RCO(2)(-)) (R = -CH(3), -C(3)H(7), -C(6)H(5)). Compou...

Introduction: In recent study both endothelium-dependent and endothelium-independent mechanisms have been reported for the action of β-adrenoceptor. The aim of this study was to investigate on the role of nitric oxide (NO) and cyclic guanosin monophosphate (cGMP) in vasodilation mechanisms of β2-adrenoceptors (β2-AR) in rat skin vessels. Methods: All drugs were injected subcutaneous into p...

In the study which was prepared based on factors that can take place in essential hypertension pathology; We aimed to investigate interactions of intensive exercise, high salt and partial NOS inhibition applications with each other, effects water-salt balance blood pressure, changes intrarenal dopaminergic system, is an important natriuretic participation oxidative stress. The rats were given e...

We evaluated the effects of Rikkunshi-to and several of its ingredients on the delay of gastric emptying induced by a nitric oxide (NO) synthase inhibitor, N-nitro-L-arginine (LNNA). After oral administration of L-NNA to rats, the gastric emptying rate at 24 h was decreased from 82.8 ± 2.4% to 53.3 ± 5.7%. The decrease of the gastric emptying rate induced by L-NNA treatment was markedly amelior...

Stress induced by ultraviolet-B (UV-B) irradiation stimulates the accumulation of various secondary metabolites in plants. Nitric oxide (NO) serves as an important secondary messenger in UV-B stress-induced signal transduction pathways. NO can be synthesized in plants by either enzymatic catalysis or an inorganic nitrogen pathway. The effects of UV-B irradiation on the production of baicalin an...

2002 2 Summary The free radical nitric oxide (NO) has several functions in various tissues. NO is well distributed in the gastrointestinal system including the pancreas and thought to be involved in the regulation of blood flow, motility and secretion. Although morphological reports provide evidence for the intrapancreatic production of NO, much less is known about the direct actions of NO exer...

Endothelium-derived relaxing factors contribute to smooth muscle relaxation. The aim of the present study was to investigate the contribution of nitric oxide (NO) produced in the endothelial cells to the vasodilatation stimulated with forskolin in rat aorta. Forskolin that directly activates adenylyl-cyclase, induced complete relaxation in phenylephrine-contracted aortas. Endothelium removal re...

Cerebral microcirculation dysfunction might play an important role in symptomatic cerebral vasospasm (CVS), and this study was to investigate whether human tissue kallikrein (HTK) can alleviate it. In this study, forty-four rabbits were randomly divided into sham-operated, subarachnoid hemorrhage-operated (SAH), SAH+HTK groups and SAH+HTK+L-NNA groups (n = 11/group). Neurological function and f...

Serotonin (5-HT, 5-hydroxytryptamine) reduces blood pressure of the conscious rat when administered chronically (1 week). 5-HT does not directly relax isolated arteries, and microsphere experiments in 5-HT-infused rats suggested that 5-HT increased flow to the splanchnic bed. We hypothesized that 5-HT increased splanchnic flow because of direct venous relaxation; our focus was thus on the super...

Coronary blood vessels are compressed by the contracting myocardium. This leads to oscillations in flow in especially the subendocardium. We examined the effects of steady and oscillating flow on isolated, cannulated subendocardial and subepicardial porcine arterioles. Steady flow-induced dilation in both vessel types, up to 12.9+/-0.8% of the passive diameter in subendocardials and 9.6+/-1.4% ...