The present study has been directed to investigate Ursodeoxycholic Acid (UDCA) effect in children, to reduce the high Liver transaminases induced by Anticonvulsant drugs (drug induced hepatitis). This idea has been driven from Cytoprotective and antioxidant properties of UDCA to be used in drug induced inflammation in Liver. Twenty two epileptic patients aged between 4 mo - 3 yr whom were under...

The semm transaminases COT (glutamate-oxalacetate-transaminase) and CPT ( glutamate-pyruvate-transaminase ), which have a determining share in intermediate metabolism, are present in the body ubiquitously and in an especially high concentration in heart muscle, liver or other parenchymatous organs and in skeletal muscle. The same is true for the serum dehydrogenase LDH (lactate-dehydrogenase) '...

The study of serum transaminases has recently entered clinical practice. In December, 1954, Wroblewsky and La Due demonstrated an increase of glutamic-oxalacetic (GOT) transaminase in the serum of patients suffering from various liver diseases and in carbon tetrachloride intoxication. In 1955, de Ritis, Coltorti and Giusti demonstrated an increase of both aspartic-ketoglutaric (GOT) and alanine...

There are no randomized clinical trials on efficacy of Entecavir in Fulminant Hepatic Failure (FHF) due to Hepatitis B Virus (HBV). Definitive treatment of FHF remains Liver Transplant. However, availability of cadaveric donor organs is limited, and many of the patients with FHF may not be candidates for Liver Transplantation. There are only few case reports on beneficial effects of Entecavir i...

Autoimmune hepatitis (AIH) is a chronic inflammation of liver with unclear etiology. It is frequently associated other autoimmune diseases, and its association with celiac disease (CD) is well established. In this article, we describe the case of a 50-year-old male with long-standing AIH taking azathioprine for 10 years, evaluated for flares in transaminases. Despite adding high-dose corticoste...

conclusions based on our results, the administration of fe3o4-nps causes dose dependent adverse effects on liver. background because of their unique magnetic properties, fe3o4 nanoparticles (fe3o4-nps) have extensive applications in various biomedical aspects. investigation of the possible adverse aspects of these particles has lagged far behind their fast growing application. objectives the cu...

Background and aims: Toxoplasmosis is a very common disease in the world. Two types of acquiredtoxoplasmosis have been detected. In the chronic toxoplasmosis, the abnormality of tissue functionis little but, in acute toxoplasmosis, function of RES system becomes interrupted. The assessment oftoxoplasma antibody with tissue enzymes in this stage is very important. Furthermore, ...

familialmediterranean fever (fmf) is a hereditary syndrome characterized by recurrent attacks of fever and serositis. liver involvement in fmf has been reported in association with amyloidosis or rarely with vasculitis.in this report, a 32 year-old man with recurrent attacks of fever, abdominal pain and arthralgia is described who had moderate increase in liver transaminases only during disease...

INTRODUCTION The therapy of patients with psoriasis and liver disease can be a challenge due to the increased risk of adverse effects from traditional systemic treatments; in addition, although the anti-tumor necrosis factor agents are considered safer, they have also been associated with drug-induced liver injury and reactivation of viral hepatitis. Ustekinumab has a different mechanism of act...

Objective(s):  Protective effects of different extracts and essential oil from Pimpinella anisum           L. seeds were examined against carbon tetrachloride (CCl4)-induced toxicity. The parameters such as serum transaminases, lactate dehydrogenase activity, hepatic glutathione content, liver lipid peroxidation and histopathological changes of liver were assessed as toxicity markers. In the in...