In liver diagnostics, a simple, non-invasive test with high sensitivity and specificity is permanently being sought in order to assess the degree of liver damage. In addition to liver biopsy, algorithms using blood parameters or elastometry are used in clinical practice. However, these methods do not provide information about the true liver reserve, so the liver breath test seem to be a promisi...

UNLABELLED Preoperative assessment of liver function and prediction of postoperative functional reserve are important in patients scheduled for liver resection. While determination of absolute liver function currently mostly relies on laboratory tests and clinical scores, postoperative remnant liver function is estimated volumetrically using imaging data obtained with computed tomography (CT) o...

LFTs are not specific to specific systems or disease processes, yet abnormalities may indicate significant or serious disease. Interpreting abnormal LFTs and trying to diagnose any underlying liver disease is a common scenario in Primary Care. Single abnormalities in LFTs are difficult to localise and diagnose [2] . However, the pattern of abnormalities tests helps determine origin of the issue...

Objective(s): Gallic acid (GA) is a highly effective antioxidant, which its beneficial effects are well known, but its impact on expression of microRNAs (miRs) following hepatic ischemia-reperfusion (I/R) is not well recognized. Therefore, the current research was designed to specify the beneficial effect of GA on miRs (122 and 34a), liver functional tests, and histopathological alterations bey...

Serum levels of aspartate aminotransferase and alanine aminotransferase that exceed 1000 IU/L indicate acute viral hepatitis (A, B and, rarely, C), acute drug toxicity (eg, acetaminophen overdose or isoniazid hepatotoxicity), or ischemic liver injury. In chronic hepatitis (ie, hepatitis B or C or autoimmune), values range from mildly elevated to usually less than 400 IU/L. Elevated levels of al...

The liver may be regarded as a system of branching bile ducts which terminate in numerous blind tubules, the bile canaliculi. The walls are formed by the liver cells, which are externally in contact with the capillaries of the portal venous system and the hepatic arterial system: these cells are homogeneous and show no obvious signs of differentiation or specialization. But in spite of its anat...

Background & Aims: Liver ischemia-reperfusion (IR) is one of the common consequences of liver surgery, especially during liver transplantation which results in organ dysfunction. Acute hepatic injury causes systematic inflammatory responses which may finally lead to functional disturbances in remote organs such as heart, lungs and kidneys. In this study, the effects of a potent inhibitor of inf...

abstract diabetes is one of the most common metabolic diseases and in the long term affects many parts of body, including liver and kidneys. this study was to investigate alcoholic extract effect of alhagi camelorum on functional tests of liver and kidney in diabetic rats induced by streptozotocin. in this study, 28 wistar male rats were divided into the four groups (n = 7): non-diabetic contro...

Purpose: To assess the reliability of neurocognitive and functional performance tests in athletes with and without functional ankle instability (FAI). Methods: In this methodological study, 20 athletes with unilateral functional ankle instability (mean age [SD]: 23.40[2.58] y; mean height[SD]: 1.77[0.11] m; mean weight[SD]: 67.00[13.18] kg) and 20 uninjured athletes (mean age[SD]: 23.05[2.72] ...

Breath tests for "dynamic" liver function evaluation have been proposed several years ago. A variety of carbon-labelled breath tests for the assessment of mitochondrial, microsomal and cytosolic liver function have been described with the aim to increase data on liver disease staging, prognosis, and response to therapy. In the last years a great interest is developed about the use of breath tes...