Drug-induced liver toxicity dominates the reasons for pharmaceutical product ban, withdrawal or non-approval since the thalidomide disaster in the late-1950s. Hopes to finally solve the liver toxicity test dilemma have recently risen to a historic level based on the latest progress in human microfluidic tissue culture devices. Chip-based human liver equivalents are envisaged to identify liver t...

Introduction: Orexins are novel neuropeptides that are localized in neurons in the lateral hypothalamus. They are implicated in a wide variety of physiological functions. Orexin peptides and receptors are found in many peripheral organs such as kidneys. It has been demonstrated that exogenous orexin-A can induce protective effects against ischemia–reperfusion injury in many organs. The goal ...

Background: Considering the association between cardiac abnormalities and non-alcoholic fatty liver disease (NAFLD), the present study aimed to evaluate the relationship between biopsy-proven NAFLD and functional echocardiographic parameters, including left ventricular (LV) global longitudinal strain (GLS) in asymptomatic individuals. Methods: Thirty asymptomatic patients with liver biopsy-prov...

introduction: anterior cruciate ligament (acl) rupture is one of the most common sport injuries. despite present progresses in conservative and surgical treatment methods for acl, the rate of return to pre-injury level (rtp) is low. fear of movement/reinjury (kinesiophobia) is a major hindrance to rtp in these patients. the aim of the following research was to investigate functional tests’ effe...

UNLABELLED Patients undergoing orthotopic liver transplantation are at high risk of bleeding complications. Several Authors have shown that thromboelastography (TEG)-based coagulation management and the administration of fibrinogen concentrate reduce the need for blood transfusion. METHODS We conducted a single-center, retrospective cohort observational study (Modena Polyclinic, Italy) on 386...