Background: Protein-protein interactions do not provide any direct information re‌garding the domains within the proteins that mediate the interactions. The majority of proteins are multi domain proteins and the interaction between them is often defined by the pairs of their domains. Most of the former studies focus only on interacting do‌main pairs. However they do not consider the in...

objective: to evaluate the effect of niprd-am1 on cyp3a4 in order to generate clinically significant data for its safe and efficacious use. materials and methods: niprd-am1 is a phytomedicine developed from aqueous root extracts of nauclea latifolia smith (rubiaceae) for the treatment of uncomplicated malaria. the effect of niprd-am1 on cyp3a4 was measured with and without the addition of niprd...

this study demonstrates the spectral data for two triarylmethane dyes, malachite green (mg) and crystal violet (cv) at room temperature. effects of micellar environment, and crown ether addition on the spectral behaviour of the dyes were studied using absorption spectroscopic method. the dye-anionic surfactant interactions in micellar media were investigated. the chosen surfactants with differe...

the density and viscosity values at t= (293.15 to 323.15) k for binary mixtures of nitromethane with 2-propanol, 2-butanol and 2-pentanol were measured over the entire composition range. from the experimental data, excess molar volumes, thermal expansion coefficients, excess thermal expansions, partial molar volumes at infinite dilution and deviations in viscosity were calculated. the results w...

background:     purpose:     methods:     results     conclusion     rug interactions , active training : drug interactions are common medical errors in gorgan province and training can decrease their rate. keywords. d   : overall prevalence of drug interactions was 8.93%, of which 6.55% were major, 65.58% moderate and 27.87% minor. interactions were mostly seen among male doctors. the physicia...

concomitant use of several drugs by icu( intensive care unit) patients is often unavoidable. in these patients, pharmacokinetic drug interactions are very likely. the current study was designed to evaluate these interactions in patients hospitalized in an icu of a teaching hospital in tehran, iran. a questionnaire was designed and used to collect study data. the study was done in the icu of a t...

Correct prescription writing habits could have a great influence on the fate of drug therapy as well as the health of patients. One of the major types of errors in prescriptions is the "errors of commission". In this study attempts were made to examine 519 prescriptions of the internal ward of Ayatollah Taleghani teaching hospital over a period of 3 months in terms of the nature and extent of t...

background: reciprocal drug interactions are among the most common causes of adverse drug reactions. we investigated the incidence and related risk factors associated with mutual drug interactions in relation to prescriptions written in the neurology wards of two major teaching hospitals in shiraz, southern iran. methods: data was collected from hand-written prescriptions on a daily basis. mutu...