In 1949 John Cade, a senior medical officer of the Victorian Department of Mental Hygiene, Australia, investigated the effects of lithium carbonate and lithium citrate on the mental state of patients suffering from mania or manic depression (1). This illness is sometimes known as bipolar disorder. Lithium was regarded as a controversial medication, which had resulted in the deaths of some patie...

In a fatal case of self-poisoning with lithium carbonate there was a progressive increase in serum lithium concentration for 48 hours after ingestion of the overdose. It is suggested that the continuous increase in serum lithium concentration reflects prolonged absorption of lithium from relatively insoluble aggregates of lithium carbonate in the gastrointestinal tract. In this case there was a...

ocular dryness is a well-recognized adverse side effect of many topical and systemic medications. in psychiatry, patients who have consumed such drugs as lithium carbonate and sodium valproate frequently experience dry eye symptoms. the purpose of this study was to compare tear film stability between patients who use these drugs with those patients who are not on medication.after obtaining info...

For more than sixty years lithium carbonate has been used in medicine. However, during its administration different side effects including oxidative stress can occur. Selenium belongs to essential elements possessing antioxidant properties. This study aimed at evaluating if selenium could be used as a protective adjuvant in lithium therapy. The experiment was performed on four groups of Wistar ...

Because adenine is effective for managing cases of radiation-induced and drug-induced leukopenia, it may be effective in cases of antipsychotic-induced leukopenia and neutropenia. Here, we report our experience with patients with leukopenia and neutropenia caused by an antipsychotic overdose or discontinuation of lithium carbonate, in whom adenine administration ameliorated the white blood cell...

Introduction: Lithium salts are known as effective psychotropic medicine for treatment bipolar disorder and may be used to treat alcoholism, schizoaffective disorders, and cluster headaches. The antioxidant activity and immunomodulatory effects of prospective lithium compounds have been investigated in this work. Materials and Methods: The antioxidant properties were studied by the voltammetry...

From the Research Division, J. T. Baker Chemical Co., Phillipsburg, N. J. 08865. 1 Paper IV in the series “The Practical Analysis of High-Purity Chemicals.” Presented at the 22nd National Meeting of the AACC, Buffalo, N.Y., July 1970. Received April22, 1971; accepted June 3, 1971. Calcium carbonate Lithium carbonate Magnesium acetate Potassium chloride Potassium monobasic phosphate Sodium chlor...

There is an error within the fourth sentence of the Abstract. The correct sentence is: Transgenic mice (Cg-Tg(PDGFB-APPSwInd)20Lms/2J) and their non-transgenic litter mate genetic controls were treated with lithium carbonate (0.25mg/Kg/day in drinking water) for 16 or 8 months starting at two and ten months of age, respectively. There is an error within the first sentence of the second paragrap...

Thirty patients with rapid cycling bipolar affective disorder were studied prospectively to assess presence and severity of thyroid hypofunction. Seven (23%) were classified as having grade I hypothyroidism, while 8 (27%) had grade II and 3 (10%) had grade III abnormalities. This prevalence of grade I hypothyroidism is significantly greater than that reported in studies of unselected bipolar pa...

Psoriasis is a common, inflammatory, and proliferative disease of the skin. The exact cause of psoriasis is unclear, but it is thought to be a multifactorial disease triggered by both genetic and environmental factors such as trauma, infection, alcohol, smoking, stress, and drugs. It is established that lithium carbonate induce and/or exacerbate psoriasis [1]. Herein, we report a case of exacer...