Corresponding author: Bong Soo Cha Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Korea E-mail: [email protected] We sincerely appreciate the interest and comments regarding our study, “Balsamic Vinegar Improves High Fat-Induced Beta Cell Dysfunction via Beta Cell ABCA1,” which was published in Diabetes & Metabolism Journal 2012;36...

AIMS Leptin resistance has been associated with cardiac lipotoxicity; however, whether leptin resistance is a risk factor associated with cardiac lipotoxicity at different time points in diet-induced obesity is unclear. The objective of this study was to evaluate this relationship. MAIN METHODS Male Wistar rats were fed a normal chow diet (12% from fat) or a high-fat diet (49% from fat) for 1...

CONTEXT Lipotoxicity is a risk factor for developing obesity-related metabolic complications, including non-alcoholic fatty liver disease, type 2 diabetes (DM2), cardiovascular disease and stroke. Yet, the mechanisms underlying the development of lipotoxicity itself remain poorly understood. Here, we investigated whether glucose intolerance aggravates lipotoxicity by evaluating the association ...

Obesity and diabetes are associated with excessive inflammation and impaired wound healing. Increasing evidence suggests that macrophage dysfunction is responsible for these inflammatory defects. In the setting of excess nutrients, particularly dietary saturated fatty acids (SFAs), activated macrophages develop lysosome dysfunction, which triggers activation of the NLRP3 inflammasome and cell d...

NEFA (non-esterified 'free' fatty acid)-mediated lipotoxicity plays a critical role in the pathogenesis of NASH (non-alcoholic steatohepatitis). In the light of the growing need for new therapeutic options for NASH, we investigated the action of A2aR (adenosine A(2a) receptor) stimulation against lipotoxicity. The effects of the A(2a)R agonist CGS21680 [2-p-(2-carboxyethyl)phenethylamino-5'-N-e...

Excessive fat ectopically deposited in the non-adipose tissues is considered as one of leading causes myopathy. The aim this study was to investigate role Dihydroartemisinin (DHA) palmitate (PAL)-incubated H9c2 cells (lipotoxicity-induced cell injury model). Cell viability PAL-treated determined by MTT assay, and apoptotic regulators were examined qRT-PCR western blot analysis, absence or prese...

Lipid droplets (LD) play a central role in lipid homeostasis by controlling transient fatty acid (FA) storage and release from triacylglycerols stores, while preventing high levels of cellular toxic lipids. This crucial function in oxidative tissues is altered in obesity and type 2 diabetes. Perilipin 5 (PLIN5) is a LD protein whose mechanistic and causal link with lipotoxicity and insulin resi...

Peroxisome proliferator-activated receptor (PPAR)-α, a lipid-sensing transcriptional factor, serves an important role in lipotoxicity. We evaluated whether fenofibrate has a renoprotective effect by ameliorating lipotoxicity in the kidney. Eight-week-old male C57BLKS/J db/m control and db/db mice, divided into four groups, received fenofibrate for 12 weeks. In db/db mice, fenofibrate ameliorate...

Obesity and metabolic syndrome are associated with cognitive decline dementia. Palmitic acid (PA) is increased in the cerebrospinal fluid of obese patients impairment. This study was therefore designed to examine fatty (FA) lipotoxicity BV2 microglia cells. We found that PA induced time- dose-dependent decrease cell viability increase death without affecting cycle profile did not depend on surf...