Kanker melanoma merupakan sebuah keganasan yang terjadi pada sel melanosit. Karakteristik dari kanker ini yaitu tonjolan dan warna tidak beraturan kulit. Pengobatan digunakan saat salah satunya adalah agen kemoterapi vemurafenib. Seperti telah diketahui, dapat menyebabkan berbagai efek samping tubuh. Oleh karena itu, dilakukan pencarian senyawa lain berpotensi menghasilkan lebih sedikit. Peneli...

The control of malaria is challenged by drug resistance, and new antimalarial drugs are needed. New drug discovery efforts include consideration of hybrid compounds as potential multitarget antimalarials. Previous work from our group has demonstrated that hybrid structures resulting from cinnamic acid conjugation with heterocyclic moieties from well-known antimalarials present improved antimala...

New ligands are needed to improve diagnostics and treatment of SSTR2 expressing tumors. We implemented a procedure to identify ligands based on computer processing methods. A multistep procedure was used. Search entries were taken from National Cancer Institute database. Application of criteria defined by the Lipinski rules reduced the initial data set. Then a pharmacophore criterion including ...

In this study, physicochemical properties of 49 compounds extracted from anti-inflammatory sponge species with the aim of ADMET test and Lipinski rule of five have been determined. Fourteen compounds, which showed best results, were subjected to molecular docking studies with IL-17. Among these compounds, Four compounds with low binding energy were obtained. These compounds, namely, frondosins ...

Novel derivative of isoniazid containing 1,3,4-oxadiazole pharmacophore has been synthesized. The chemical structure the compound was characterized and confirmed by using FT-IR 1H-NMR spectroscopy.
 
 desired tested against gram-positive gram-negative bacteria agar well-diffusion technique for their ability as antibacterial agent showed good activity bacteria. In addition, ADME evalua...

receptor stimulation leads to cardiac hypertrophy in rat neonatal myocytes. J Mol Cell Cardiol 2001;33:1589–1606. 24. Nofer JR, van der Giet M, Tolle M, Wolinska I, von Wnuck Lipinski K, Baba HA, Tietge UJ, Godecke A, Ishii I, Kleuser B, Schafers M, Fobker M, Zidek W, Assmann G, Chun J, Levkau B. HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3. J Clin Invest 2004;...

Tamarind leaves (Tamarindus indica L.) are widely cultivated in tropical countries, including Indonesia. Empirically, tamarind known to have anti-diabetic properties. In this study, an in-silico method was used test the active compounds found as agents through docking score analysis. The target protein Protein Tyrosine Phosphatase (5JNT) which is related insulin resistance. Glimepiride and nati...

The appearance of brown spots and wrinkles can be a sign aging which increase the risk cancer. Compounds in broadleaf mahogany seeds (Swietenia macrophylla) contains many compounds is known to have anticancer activity. purpose this study was determine these plants potential antiaging by analyzing their molecular docking interaction on MMP-1 enzyme (matrix metalloproteinase), NEP (neprilysin), P...

Candida albicans is a normal microbiota in humans. However, the imbalance and increasing number of C. can cause infections vagina, mouth, esophagus, nails. Sap-3 plays role especially adhesion process, used as therapeutic target for C.albicans. Here an attempt has been made to analyze potential active compounds from noni (Morinda citrifolia) antifungal by molecular docking towards protein. Drug...