BACKGROUND Peroxides have been reported to contaminate lipid emulsions and amino acid solutions used in total parenteral nutrition (TPN). This is particularly disturbing in newborn infants who are prone to several diseases related to immature defense mechanisms against oxidative challenges. It is not clear whether the antioxidants in multivitamins help protect parenteral nutrients against the h...

the intake of antioxidants intake has been reported to be inversely associated with the incidence of coronary artery disease. to clarify the possible role of lipophilic antioxidants in prevention of atherosclerosis, we investigated the effects of lycopene on the susceptibility of low-density lipoprotein (ldl) to oxidative modification. in this study, “lycopene” was added to plasma and incubated...

Free radical-initiated lipid autoxidation in low density lipoprotein (LDL) has been implicated in the pathogenesis of atherosclerosis. Oxidation of the lipid components of LDL leads to a complex mixture of hydroperoxides, bicyclic endoperoxides, monocyclic peroxides, and serial cyclic peroxides. The oxidation compounds and/or their decomposition products can modify protein components, which may...

Lipid peroxides in tissues were fluorometrically determined using 1,3-diphenyl-2-thiobarbituric acid (DPTBA) as a fluorogenic reagent, and the results were compared with those obtained by the DPTBA-visible method, thiobarbituric acid (TBA)-fluorescence method, or TBA-visible method. The optimum conditions for determining lipid peroxides were analyzed by using brain homogenate. The optimum pH fo...

The effects of six flavonoids viz., apigenin, genistein, morin, naringin, pelargonidin and quercetin on the susceptibility of low-density lipoprotein (LDL) to oxidative modification were investigated. Flavonoids were added to plasma and incubated for 3 hr at 37 degrees C, and the LDL fraction was separated by ultracentrifugation. Oxidizability of LDL was estimated by measuring conjugated diene ...

The effect of aqueous solution of citric acid (CA) on the lipid stability of the European catfish (Silurus glanis) fillets during frozen storage (up to 6 months) was investigated. Rancidity development was measured by several biochemical indices (free fatty acids, peroxides and TBA) and complemented by the measurement of expressible moisture and sensory evaluation (flesh odor, consistency and f...

Lipid peroxides can be both a product and an initiator of oxidant stress. Conceivably, exercise can either increase concentrations of lipid peroxides (by causing oxidant stress), or decrease them (by accelerating peroxide breakdown). The net effect could depend on exercise intensity and nutritional intake of antioxidants. The present study examined the response of serum lipid peroxides to the c...

When paroxysmal nocturnal hemoglobinuria (PNH) erythrocytes were exposed to H(2)O(2) they lysed excessively and formed greater than normal quantities of lipid peroxides when compared to red cells of normal subjects and patients with most types of hematologic disease. It was also shown that lytic sensitivity to acidified serum was related to the enhanced lytic sensitivity to H(2)O(2). If the lip...

A polysaccharide fraction of Saccharum officinarum was tested for its effects on carbohydrate and lipid metabolism in normal rats and those fed a high sugar diet. Feeding with the high sugar diet induced an elevation of serum glucose and significant accumulation of lipid peroxides in the serum and liver. The accumulation of lipid peroxides was inhibited by combined feeding with the polysacchari...